Identification of Ovine KRTAP28-1 and Its Association with Wool Fiber Diameter

April 2019 in “ Animals ”

Lingrong Bai, Jing Wang, Huitong Zhou, Hua Gong, Jinzhong Tao, Jon G. H. Hickford

Studysummary In this study, KRTAP28-1 variants were associated with wool fibre diameter in sheep, suggesting potential as a gene marker for reducing fibre diameter.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study identified a novel keratin-associated protein gene, KRTAP28-1, in sheep, which was associated with wool fiber diameter. Researchers analyzed 383 Southdown × Merino-cross lambs and found six variants of KRTAP28-1, containing eight single nucleotide polymorphisms (SNPs) and a TG repeat polymorphism. Genotypes AB and BD were linked to smaller mean fiber diameter (MFD) compared to genotype BC, suggesting KRTAP28-1's potential as a genetic marker for improving wool traits. The study highlighted significant sequence variability and recommended further research to explore the gene's effects in a larger sheep population.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

12 / 12 results

research Identification of the Ovine Keratin-Associated Protein 26-1 Gene and Its Association with Variation in Wool Traits

29 citations , September 2017 in “Genes”

This study found that in Merino-Southdown cross sheep, the presence of the C variant of the KRTAP26-1 gene was associated with higher wool quality, including increased wool yield and staple length.

research Identification of the Ovine Keratin-Associated Protein 22-1 (KAP22-1) Gene and Its Effect on Wool Traits

42 citations , January 2017 in “Genes”

This study observed that genetic variation in the ovine KRTAP22-1 gene is linked to increased wool yield and decreased fiber curvature in sheep, indicating its potential use in breeding programs.

research Wool Keratin-Associated Protein Genes in Sheep: A Review

98 citations , May 2016 in “Genes”

This review explains the genetic diversity of sheep wool keratin-associated protein genes and explores how this variation might be leveraged for selective breeding to enhance wool fiber traits.

research The Sheep KAP8-2 Gene, A New KAP8 Family Member That Is Absent In Humans

25 citations , September 2014 in “SpringerPlus”

This study found that sheep possess a polymorphic KAP8-2 gene that shares high sequence identity with the KAP8-2 gene in goats and reindeer.

research Molecular Characterization of Caprine KRTAP13-3 in Liaoning Cashmere Goat in China

9 citations , September 2013 in “Journal of Applied Animal Research”

This study identified eight alleles of the caprine KAP13-3 gene in cashmere goats, which could influence gene expression and cashmere fiber characteristics.

research Identification and Sequence Analysis of the Keratin-Associated Protein 24-1 (KAP24-1) Gene Homologue in Sheep

51 citations , September 2012 in “Gene”

In this study, researchers identified a putative ovine KAP24-1 gene in sheep, revealing four unique DNA sequences with some similarity to KRTAP24-1 sequences from other species.

research An Updated Nomenclature for Keratin-Associated Proteins

92 citations , January 2012 in “International Journal of Biological Sciences”

This article proposes an updated naming system for keratin-associated proteins and genes, aiming to improve data storage and retrieval by including species information and genetic variation.

research Identification of the Keratin-Associated Protein 13-3 (KAP13-3) Gene in Sheep

26 citations , January 2011 in “Open Journal of Genetics”

In this study, researchers identified five unique sequences of the ovine KAP13-3 gene, with potential implications for wool traits due to observed amino acid changes.

research Characterization and Expression Analysis of the Hair Keratin Associated Protein KAP26.1

50 citations , July 2008 in “British Journal of Dermatology”

research Characterization of Human KAP24.1, A Cuticular Hair Keratin-Associated Protein with Unusual Amino Acid Composition and Repeat Structure

51 citations , January 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study identified a novel keratin-associated protein, KAP24.1, which is specifically expressed in the human scalp and located in the hair cuticle.

research Human Hair Keratin-Associated Proteins

226 citations , January 2006 in “International review of cytology”

Keratin-associated proteins are crucial for hair strength and structure.

research Human KAP Genes: Only Half of It? Extensive Size Polymorphisms in Hair Keratin-Associated Protein Genes

53 citations , June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

This article reviews extensive genetic polymorphisms in the keratin-associated proteins of human hair, indicating complexity but reporting no new clinical results and calls for further research on their potential impact on hair structure.