Characterization of an Ovine Keratin Associated Protein Gene, Producing a Protein Rich in Glycine and Tyrosine, Lacking in Cysteine

    October 2019 in “ Genes ”
    Gong Hua, Zhou, Huitong, Wang Jiqing, Li Shaobin, Luo Yuzhu, Hickford, Jonathan G. H.
    TLDR A new sheep gene, KRTAP36-1, may help breed sheep with better wool by reducing prickle factor.
    The study identified a novel ovine keratin-associated protein gene, KRTAP36-1, which produced a protein rich in glycine and tyrosine but lacking cysteine, distinguishing it from other known KAPs. This gene was located on sheep chromosome 1 and was not found in humans. The research involved 415 sheep and revealed three variants and four SNPs, with variant B associated with increased prickle factor (PF) in wool. The absence of cysteine suggested alternative cross-linking mechanisms, such as ring-stacking and hydrogen bonding, which could strengthen wool fibers. The study highlighted the potential of KRTAP36-1 as a genetic marker for breeding sheep with reduced PF, adding value to fine wool production.
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