Variation in the Caprine Keratin-Associated Protein 15-1 (KAP15-1) Gene Affects Cashmere Fibre Diameter

March 2019 in “ Archives animal breeding/Archiv für Tierzucht ”

Mengli Zhao, Huitong Zhou, Jon G. H. Hickford, Hua Gong, Jiqing Wang, Jiang Hu, Xiu Liu, Shaobin Li, Zhiyun Hao, Yuzhu Luo

KRTAP15-1 keratin-associated protein secondary hair follicles SNPs amino acids cysteine serine glycine phenylalanine mean fibre diameter keratin protein hair follicles single nucleotide polymorphisms protein building blocks

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Studysummary In this study, variation in the KRTAP15-1 gene in goats was linked to changes in cashmere fibre diameter, with specific variants showing dominant or recessive effects. Our plain-language summary of this paper — not a Tressless recommendation.

The study identified the KRTAP15-1 gene in goats and examined its variation using PCR-SSCP in 250 Longdong goats, revealing six variants with eight SNPs. Five SNPs were non-synonymous, potentially altering amino acids. KRTAP15-1 was expressed in secondary hair follicles but not in other tissues. The protein was rich in cysteine, serine, glycine, and phenylalanine. Variant A of KRTAP15-1 was associated with decreased mean fibre diameter (MFD) and appeared dominant, while variant C was linked to increased MFD and was recessive. The study concluded that KRTAP15-1 is highly polymorphic and influences cashmere fibre diameter.

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