Characterization and Expression Analysis of KAP7.1 and KAP8.2 Genes in Liaoning New-Breeding Cashmere Goat Hair Follicles

February 2010 in “ Molecular biology reports ”

Mei Jin, L. Wang, S. Li, Mengxin Xing, X. Zhang

KAP7.1 KAP8.2 hair follicles secondary hair follicles primary hair follicles qRT-PCR semi-quantitative RT-PCR in situ hybridization cortical layer inner root sheath fiber diameter cashmere quality wool quality quantitative real-time PCR semi-quantitative reverse transcription PCR

TLDR KAP7.1 and KAP8.2 genes are crucial for cashmere quality in goats.

The study investigated the expression of KAP7.1 and KAP8.2 genes in the hair follicles of Liaoning new-breeding cashmere goats to understand their role in cashmere quality. Using qRT-PCR, it was found that these genes were expressed significantly higher in secondary hair follicles compared to primary ones, with KAP7.1 being 2.28 times and KAP8.2 being 2.71 times more expressed. Semi-quantitative RT-PCR showed that these genes were not expressed in other tissues like the heart, liver, spleen, lung, and kidney, indicating their specific role in hair follicles. In situ hybridization revealed strong expression of KAP7.1 in the cortical layer and inner root sheath of both primary and secondary follicles. The differential expression of these genes in hair follicles suggested their importance in regulating fiber diameter, impacting cashmere and wool quality.

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