Identification of the Key Proteins Associated With Different Hair Types in Sheep and Goats

    September 2022 in “ Frontiers in genetics ”
    Chongyan Zhang, Qing Qin, Zhichen Liu, Xiaolong Xu, Mingxi Lan, Yingxin Xie, Zhixin Wang, Jinquan Li, Zhihong Liu
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    TLDR Different proteins are linked to the varying thickness of sheep and goat hair types.
    The study investigated the protein composition of different hair fibers in sheep and goats, with a focus on keratin and keratin-associated proteins, which are crucial for hair characteristics. It found that cashmere fibers had a significantly smaller diameter than wool, and wool was smaller than guard hair. Proteomic analysis identified 226 proteins, with keratins and keratin-associated proteins being the most abundant. The study highlighted specific proteins such as KRT85, KRTAP15-1, and KRTAP3-1 as being potentially related to fiber diameter differences. These findings could help in the development of cashmere traits and provide molecular markers for fiber type distinction. The proteomics data were made publicly available in the ProteomeXchange Consortium with the identifier PXD036685.
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