An Integrated Analysis of Cashmere Fineness lncRNAs in Cashmere Goats

April 2019 in “ Genes ”

Yawen Zheng, Sheng D. Sheng, Tai Y. Hui, Yue Chang, Jia Sun, Dan Guo, Su L. Guo, Bo J. Li, Hui Xue, Ze Y. Wang, Wen Bai

long non-coding RNAs lncRNAs RNA sequencing differentially expressed mRNAs gene ontology intermediate filament KEGG analysis sphingolipid metabolism lncRNA XLOC_008679 KRT35

TLDR lncRNA XLOC_008679 and gene KRT35 affect cashmere fineness in goats.

Researchers investigated the role of long non-coding RNAs (lncRNAs) in regulating cashmere fineness in Liaoning and Inner Mongolia cashmere goats during the anagen phase. Using RNA sequencing, they identified 437 novel lncRNAs and 3,084 differentially expressed mRNAs. Gene ontology analyses highlighted the importance of intermediate filament-related targets, while KEGG analysis pointed to sphingolipid metabolism as a significant pathway. Notably, lncRNA XLOC_008679 and its target gene KRT35 were implicated in cashmere fineness. This study provided the first insights into the lncRNA-mRNA regulatory network for cashmere fineness, aiding future fiber development research.

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