Long Noncoding RNA and Gene Expression Analysis of Melatonin-Exposed Liaoning Cashmere Goat Fibroblasts Indicating Cashmere Growth

    September 2018 in “ Naturwissenschaften ”
    Mei Jin, Mengshu Cao, Qian Cao, Jinhua Piao, Fengqin Zhao, Junjie Piao
    Image of study
    TLDR Melatonin treatment increases a specific RNA in goat cells that boosts cashmere growth.
    The study explored the impact of melatonin on cashmere growth in Liaoning cashmere goat fibroblasts by examining the expression of long noncoding RNAs (lncRNAs) and genes. Treatment with 0.2 g/L melatonin for 72 hours was found to be the most effective, leading to the upregulation of a specific lncRNA, XLOC_005914 (LncRNA MTC), which promoted fibroblast proliferation and regulated hair follicle development through NF-kB signaling. The study identified 113 differentially expressed lncRNAs after melatonin treatment, with LncRNA MTC being a key regulator of fibroblast proliferation and cashmere growth-related gene expression. Overexpression of LncRNA MTC increased the expression of keratin-associated proteins and other hair growth-related genes, while its knockdown had the opposite effect. The study suggests that LncRNA MTC mediates melatonin's effects on hair growth and could be a target for enhancing cashmere yield and quality. The number of fibroblasts or animals used was not specified.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    6 / 251 results

      community My strong recommendation for those shedding hair

      in Treatment  96 upvotes 3 years ago
      A user with aggressive male pattern baldness found that topical melatonin significantly reduced their hair shedding to 1 or 2 hairs per day and noticed some thickening of side hair. They tried many treatments like finasteride and minoxidil with little success, but topical melatonin showed immediate results in reducing hair loss.

      community My Progress - 56 y/o with NW7 hairloss

      in Progress Pictures  70 upvotes 3 years ago
      A 57-year-old man with severe hair loss since age 14 tried various hair loss treatments over two years, including finasteride, dutasteride, minoxidil, and supplements, with some minor regrowth. He also experimented with topical treatments and microneedling, but results were not cosmetically significant.

      community How long have you tried topical melatonin?

      in Treatment  4 upvotes 8 months ago
      The conversation is about the effectiveness of topical melatonin for hair loss, asking for details on dosage, frequency, duration of use, results, and brand information. An update includes a skeptical view on the studies regarding melatonin's effectiveness.

      community Melatonin a possible tool to help fight AGA hair loss.

      in Research/Science  54 upvotes 3 years ago
      Topical melatonin may help reduce hair loss and increase hair thickness in people with androgenetic alopecia (AGA), with some studies showing positive results. It can be mixed with minoxidil for application, and its effectiveness might be enhanced when used with micro-needling, but results may vary among individuals.

    Related Research

    5 / 5 results