Single-Cell Sequencing Reveals the New Existence Form of Dermal Papilla Cells in the Hair Follicle Regeneration of Cashmere Goats

    February 2022 in “ Genomics ”
    Feng Yang, Rui Li, Cun Zhao, Tianyu Che, Jun-tao Guo, Yuchun Xie, Zhi-Xin Wang, Jinquan Li, Zhihong Liu
    TLDR Researchers discovered new cell types in goat hair follicles that could help understand hair regrowth and human hair loss.
    The study utilized cashmere goats, which have distinct hair follicle periodicity, to investigate dermal papilla (DP) cell differentiation using single-cell RNA sequencing. Researchers identified four intermediate cell states of DP cells, each with specific roles: Intermediate-cell-10 is crucial for growth and maintenance, intermediate-cell-1 is involved in apoptosis and shedding, intermediate-cell-0 initiates new follicular cycles and migration, and intermediate-cell-15 are potential DP progenitor cells. These findings offer new insights into hair regrowth and provide a molecular framework for understanding DP cell mechanisms, potentially informing human hair loss research.
    Discuss this study in the Community →

    Research cited in this study

    16 / 16 results

    Related Community Posts Join

    6 / 1000+ results
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  862 upvotes 3 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  41 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Verteporfin and Microneedling

      in Treatments 8 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 6 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community HairClone: Good info from their site

      in Technology  10 upvotes 2 years ago
      HairClone aims to rejuvenate miniaturizing hair follicles through follicle banking and cell expansion, with treatments potentially available in the UK by 2022. The process involves extracting, storing, and cloning hair follicles, but full regenerative treatments will take many years to develop.

    Related Research

    6 / 6 results