Single-Cell Sequencing Reveals the New Existence Form of Dermal Papilla Cells in the Hair Follicle Regeneration of Cashmere Goats

February 2022 in “ Genomics ”

Feng Yang, Rui Li, Cun Zhao, Tianyu Che, Jun-tao Guo, Yuchun Xie, Zhi-Xin Wang, Jinquan Li, Zhihong Liu

dermal papilla cells hair follicle regeneration single-cell RNA sequencing apoptosis follicular cycles DP progenitor cells

Studysummary This study used cashmere goats to map the differentiation of dermal papilla stem cells and identified key intermediate cell states involved in hair follicle regeneration. Our plain-language summary of this paper — not a Tressless recommendation.

The study utilized cashmere goats, which have distinct hair follicle periodicity, to investigate dermal papilla (DP) cell differentiation using single-cell RNA sequencing. Researchers identified four intermediate cell states of DP cells, each with specific roles: Intermediate-cell-10 is crucial for growth and maintenance, intermediate-cell-1 is involved in apoptosis and shedding, intermediate-cell-0 initiates new follicular cycles and migration, and intermediate-cell-15 are potential DP progenitor cells. These findings offer new insights into hair regrowth and provide a molecular framework for understanding DP cell mechanisms, potentially informing human hair loss research.

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This study found that deleting the Hes1 gene disrupts hair regeneration by delaying anagen initiation and shortening the anagen phase, suggesting it's crucial for maintaining hair cycle homeostasis.

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13 citations , September 2018 in “Scientific Reports”

In this study, researchers found that microRNAs and specific target genes, such as MiR-195 and genes like CHP1, SMAD2, FZD6, and SIAH1, play significant roles in regulating hair follicle initiation in cashmere goats.

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7 citations , March 2018 in “Asian-Australasian journal of animal sciences”

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