Single-Cell Sequencing Reveals the New Existence Form of Dermal Papilla Cells in the Hair Follicle Regeneration of Cashmere Goats

February 2022 in “ Genomics ”

Feng Yang, Rui Li, Cun Zhao, Tianyu Che, Jun-tao Guo, Yuchun Xie, Zhi-Xin Wang, Jinquan Li, Zhihong Liu

dermal papilla cells hair follicle regeneration single-cell RNA sequencing apoptosis follicular cycles DP progenitor cells

TLDR Researchers discovered new cell types in goat hair follicles that could help understand hair regrowth and human hair loss.

The study utilized cashmere goats, which have distinct hair follicle periodicity, to investigate dermal papilla (DP) cell differentiation using single-cell RNA sequencing. Researchers identified four intermediate cell states of DP cells, each with specific roles: Intermediate-cell-10 is crucial for growth and maintenance, intermediate-cell-1 is involved in apoptosis and shedding, intermediate-cell-0 initiates new follicular cycles and migration, and intermediate-cell-15 are potential DP progenitor cells. These findings offer new insights into hair regrowth and provide a molecular framework for understanding DP cell mechanisms, potentially informing human hair loss research.

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