Hes1 Regulates Anagen Initiation and Hair Follicle Regeneration Through Modulation of Hedgehog Signaling

November 2019 in “ Stem Cells ”

Wei-Jeng Suen, Shao Li, Liang-Tung Yang

Hes1 anagen phase hair follicle regeneration Hedgehog signaling pathway Shh signaling hair cycle homeostasis alopecia hair growth hair loss

TLDR Hes1 protein is important for hair growth and regeneration, and could be a potential treatment for hair loss.

A study from three years ago found that the Hes1 protein plays a crucial role in regulating hair growth and follicle regeneration in mice by modulating the Hedgehog signaling pathway. Its absence leads to delayed hair growth and reduced follicle regeneration, making it a potential target for hair loss and alopecia treatments. Hes1 enhances Shh signaling during the anagen phase, which helps maintain hair cycle homeostasis. The study suggests that Hes1 could be a potential therapeutic strategy for controlling hair growth and promoting hair follicle regeneration.

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