Hes1 Regulates Anagen Initiation and Hair Follicle Regeneration Through Modulation of Hedgehog Signaling

November 2019 in “ Stem Cells ”

Wei-Jeng Suen, Shao Li, Liang-Tung Yang

Hes1 anagen phase hair follicle regeneration Hedgehog signaling pathway Shh signaling hair cycle homeostasis alopecia hair growth hair loss

TLDR Hes1 protein is important for hair growth and regeneration, and could be a potential treatment for hair loss.

A study from three years ago found that the Hes1 protein plays a crucial role in regulating hair growth and follicle regeneration in mice by modulating the Hedgehog signaling pathway. Its absence leads to delayed hair growth and reduced follicle regeneration, making it a potential target for hair loss and alopecia treatments. Hes1 enhances Shh signaling during the anagen phase, which helps maintain hair cycle homeostasis. The study suggests that Hes1 could be a potential therapeutic strategy for controlling hair growth and promoting hair follicle regeneration.

View this study on stemcellsjournals.onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells

research The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells

35 citations, July 2018 in “Cell Reports”

The study found that a specific area of the hair follicle helps start hair growth by reducing the blocking effects on certain cells and controlling growth signals.

research Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer

72 citations, November 2017 in “Journal of developmental biology”

The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.

research Msi2 Maintains Quiescent State of Hair Follicle Stem Cells by Directly Repressing the Hedgehog Signaling Pathway

29 citations, January 2017 in “Journal of Investigative Dermatology”

The Msi2 protein helps keep hair follicle stem cells inactive, controlling hair growth and regeneration.

research Resting No More: Redefining Telogen, the Maintenance Stage of the Hair Growth Cycle

120 citations, November 2014 in “Biological Reviews”

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

research Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

396 citations, May 2011 in “Cell stem cell”

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

research Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis

61 citations, January 2011 in “PloS one”

Notch signaling is essential for healthy skin and hair follicle maintenance.

research Epidermal Notch Signaling: Differentiation, Cancer, and Adhesion

253 citations, April 2008 in “Current opinion in cell biology”

Notch signalling helps skin cells differentiate and prevents tumors.

research Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents

127 citations, December 2007 in “Journal of Investigative Dermatology”

Mice hair growth patterns get more complex with age and can change with events like pregnancy or injury.

research Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway

113 citations, September 2005 in “Journal of Investigative Dermatology”

Applying a special compound can promote hair growth without harmful side effects.

research Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells

384 citations, June 2005 in “Genes & development”

β-catenin is essential for stem cell activation and proliferation in hair follicles.

Similar Research

5 / 141 results

research A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells

31 citations, August 2021 in “Stem Cell Research & Therapy”

The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.

research Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing

5 citations, April 2022 in “Frontiers in Medicine”

Hair and skin healing involve complex cell interactions controlled by specific molecules and pathways, and hair follicle cells can help repair skin wounds.

research Thyroid Hormone Receptor Agonist Promotes Hair Growth in Mice

1 citations, February 2022 in “Clinical, Cosmetic and Investigational Dermatology”

TDM10842, a thyroid hormone receptor activator, was found to effectively promote hair growth in mice.

Non-Invasive Assessment of Hair Regeneration in Androgenetic Alopecia Mice In Vivo Using Two-Photon and Second Harmonic Generation Imaging

research Non-Invasive Assessment of Hair Regeneration in Androgenetic Alopecia Mice In Vivo Using Two-Photon and Second Harmonic Generation Imaging

September 2023 in “Biomedical Optics Express”

New imaging techniques show testosterone delays hair growth and shrinks follicles in mice, but have limited depth for viewing.

research Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles

21 citations, May 2022 in “Frontiers in Cell and Developmental Biology”

Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.