NF-κB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in Various Pelage Hair Follicle Types
September 2017
in “
The journal of investigative dermatology/Journal of investigative dermatology
”
NF-κB hair follicle HF cycle secondary hair germ telogen anagen inner root sheath HF matrix hair fiber morphogenesis NF-κB suppression telogen-anagen transition awl hair zigzag hair noncanonical signaling guard hair stem cell activation stem cell maintenance hair cycle hair germ hair growth phases hair root sheath hair matrix hair formation hair growth transition hair types hair signaling hair stem cells
TLDR NF-κB is crucial for different stages and types of hair growth in mice.
The study investigated the role of the transcription factor NF-κB in the hair follicle (HF) cycle of adult mice. Using NF-κB reporter mouse models, researchers found strong NF-κB activity in the secondary hair germ during late telogen and early anagen phases, indicating its role in HF stem/progenitor cell activation. NF-κB activity was also observed in the inner root sheath and HF matrix during mid-anagen, suggesting involvement in hair fiber morphogenesis. An inducible NF-κB suppression model revealed that NF-κB functions varied by hair type: it was crucial for the telogen-anagen transition in awl and zigzag HFs, necessary for zigzag hair bending via noncanonical signaling, and essential for guard HF cycling, highlighting its importance in stem cell activation and maintenance.
