Expression and Localization of Sox10 During Hair Follicle Morphogenesis and Induced Hair Cycle

January 2021 in “ International Journal of Medical Sciences ”

Jing Jing, Peng Xu, Jiali Xu, Yuxin Ding, Xiaoshuang Yang, Xiaoqin Jin, Lijuan Zhou, Yuhong Chen, Xianjie Wu, Zhongfa Lu

Sox10 hair follicle morphogenesis hair cycle hair germ hair peg telogen phase hair bulge germ cell cap hair follicle stem cells anagen phase catagen phase keratinocytes outer root sheath HFSCs ORS

TLDR Sox10 is important for hair follicle development and hair growth cycles.

The study investigated the role of Sox10 in hair follicle morphogenesis and the hair cycle, using immunohistochemical and immunofluorescence analysis. Sox10 was found to be expressed in the hair germ and peg during morphogenesis. In the telogen phase, Sox10 was present in the hair bulge and germ cell cap, where hair follicle stem cells (HFSCs) are located. During anagen and catagen phases, Sox10 was observed in the epithelial portions, such as the strands of keratinocytes and the outer root sheath (ORS). These findings suggested that Sox10 played a role in early hair follicle development and the regulation of postnatal hair follicle cycling.

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