Decorin Promotes Proliferation and Migration of ORS Keratinocytes and Maintains Hair Anagen in Mice

    August 2018 in “ Experimental Dermatology ”
    Lijuan Zhou, Jing Jing, Han Wang … Lu Zhang
    Studysummary This study found that DECORIN promotes the proliferation and migration of outer root sheath keratinocytes in vitro and maintains the hair anagen phase in mice.
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    Research cited in this study 16

    1. Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy Cancer Research · 2017
    2. Beta-Catenin Is Involved in Oleanolic Acid-Dependent Promotion of Proliferation in Human Hair Matrix Cells in an In Vitro Organ Culture Model Fitoterapia · 2017
    3. Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process Clinical, Cosmetic and Investigational Dermatology · 2017
    4. Novel ALK5 Inhibitor TP0427736 Reduces TGF-β Induced Growth Inhibition in Human Outer Root Sheath Cells and Elongates Anagen Phase in Mouse Hair Follicles Pharmacological Reports · 2017
    5. An Investigation of Crosstalk Between Wnt/β-Catenin and Transforming Growth Factor-β Signaling in Androgenetic Alopecia Medicine · 2016
    6. A Newly Discovered Linkage Between Proteoglycans and Hair Biology: Decorin Acts as an Anagen Inducer Experimental Dermatology · 2014
    7. In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators Nature Cell Biology · 2014
    8. VEGF165 Modulates Proliferation, Adhesion, Migration, and Differentiation of Cultured Human Outer Root Sheath Cells from Central Hair Follicle Epithelium Through VEGFR-2 Activation In Vitro Journal of Dermatological Science · 2013
    9. Mammalian Target of Rapamycin Complex 1 (mTORC1) May Modulate the Timing of Anagen Entry in Mouse Hair Follicles Experimental dermatology · 2012
    10. Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration Journal of Investigative Dermatology · 2012
    11. Conditioned Media Obtained from Human Outer Root Sheath Follicular Keratinocyte Culture Activates Signalling Pathways That Contribute to Maintenance of Hair-Inducing Capacity and Increases Trichogenicity of Cultured Dermal Cells Experimental Dermatology · 2012
    12. VEGF Upregulates VEGF Receptor-2 on Human Outer Root Sheath Cells and Stimulates Proliferation Through ERK Pathway Molecular Biology Reports · 2012
    13. Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia British Journal of Dermatology · 2012
    14. L-Carnitine-L-Tartrate Promotes Human Hair Growth In Vitro Experimental Dermatology · 2007
    15. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    16. The Biology of Hair Follicles The New England Journal of Medicine · 1999

    Related research 5

    1. Beta-Catenin-Mediated Hair Growth Induction Effect of 3,4,5-Tri-O-Caffeoylquinic Acid Aging · 2019
    2. Activation of Beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth PLOS ONE · 2016
    3. A Newly Discovered Linkage Between Proteoglycans and Hair Biology: Decorin Acts as an Anagen Inducer Experimental Dermatology · 2014
    4. Expression Of Sfrp2 Is Increased In Catagen Of Hair Follicles And Inhibits Keratinocyte Proliferation Annals of Dermatology · 2014
    5. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010