Conditioned Media Obtained from Human Outer Root Sheath Follicular Keratinocyte Culture Activates Signalling Pathways That Contribute to Maintenance of Hair-Inducing Capacity and Increases Trichogenicity of Cultured Dermal Cells

August 2012 in “ Experimental Dermatology ”

Mi-Hye Lee, Sungbin Im, Sug Kyun Shin, Mi Hee Kwack, Sang-Eun Jun, Moon Kyu Kim, Jung Chul Kim, Young Kwan Sung

TLDR The substance from human hair root cells can help maintain hair growth and make skin cells more capable of growing hair.

In 2012, a study explored the impact of follicular keratinocyte-conditioned media (FKCM) on the hair-inducing ability of cultured dermal cells. The research discovered that FKCM treatment activated BMP and ß-catenin signalling pathways, both known to aid hair growth. Additionally, FKCM showed increased levels of proteins IGFBP-7, IL-8, OPG, and uPA. The study concluded that FKCM could be useful in hair reconstitution research and potentially be used to expand a patient's own dermal cells for cell-based hair loss treatments.

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