Conditioned Media Obtained from Human Outer Root Sheath Follicular Keratinocyte Culture Activates Signalling Pathways That Contribute to Maintenance of Hair-Inducing Capacity and Increases Trichogenicity of Cultured Dermal Cells
July 2012
in “
Experimental Dermatology
”
follicular keratinocyte-conditioned media FKCM BMP signalling pathway ß-catenin signalling pathway IGFBP-7 IL-8 OPG uPA hair-inducing capacity trichogenicity dermal cells hair reconstitution cell-based hair loss treatments BMP beta-catenin insulin-like growth factor binding protein 7 interleukin 8 osteoprotegerin urokinase-type plasminogen activator
TLDR The substance from human hair root cells can help maintain hair growth and make skin cells more capable of growing hair.
In 2012, a study explored the impact of follicular keratinocyte-conditioned media (FKCM) on the hair-inducing ability of cultured dermal cells. The research discovered that FKCM treatment activated BMP and ß-catenin signalling pathways, both known to aid hair growth. Additionally, FKCM showed increased levels of proteins IGFBP-7, IL-8, OPG, and uPA. The study concluded that FKCM could be useful in hair reconstitution research and potentially be used to expand a patient's own dermal cells for cell-based hair loss treatments.
