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This study found that trans-3,4'-Dimethyl-3-hydroxyflavanone reduces active TGF-beta2 levels in human keratinocytes, suggesting it may enhance hair growth by suppressing the TGF-beta2 activation pathway.

This study found that neonatal mice without the urokinase-type plasminogen activator (uPA) gene had reduced epidermal proliferation rates, suggesting uPA's involvement in promoting keratinocyte proliferation.

In this study, treatment with human follicular keratinocyte-conditioned media improved the trichogenicity of cultured dermal cells by activating key signalling pathways, suggesting its potential use in cell therapy for hair loss.

This study found that women with PCOS had significantly elevated plasma levels of PAI-1, which correlated with insulin resistance and obesity.

This study observed that PAI-2 is consistently expressed in differentiating cells of murine hair and nail, suggesting it may function as a marker of differentiation and possibly protect against premature cell death.