Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin

    June 2019 in “ Stem cells
    Alizée Le Riche, Édith Aberdam, Laëtitia Marchand, Elie Frank, Colin A.B. Jahoda, Isabelle Petit, Sylvie Bordes, B. Closs, Daniel Aberdam
    TLDR Special particles from skin cells can promote hair growth by activating a specific growth signal.
    The study demonstrated that extracellular vesicles (EVs) from activated dermal fibroblasts significantly promoted hair follicle growth by stimulating dermal papilla cells to secrete Norrin, which activated the β-catenin pathway in hair follicular keratinocytes. The research identified Norrin as a novel player in hair follicle physiopathology and highlighted the potential of EVs as a therapeutic approach for promoting hair growth and treating conditions like alopecia. The findings provided new insights into the cellular interactions and molecular mechanisms involved in hair follicle regeneration.
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