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GlossaryOuter Root Sheath Keratinocytes (ORS keratinocytes)

specialized cells in the hair follicle's outer layer

Outer Root Sheath Keratinocytes are specialized cells found in the outer layer of the hair follicle. These cells play a crucial role in the growth and regeneration of hair, as they provide structural support and contribute to the formation of the hair shaft. For professionals, it's important to note that these keratinocytes are involved in the hair cycle's anagen (growth) phase and can be a focus in studies related to hair loss and treatments for conditions like alopecia.

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research Decorin Promotes Proliferation and Migration of ORS Keratinocytes and Maintains Hair Anagen in Mice

10 citations, August 2018 in “Experimental Dermatology”

Decorin helps hair cells grow and move, and keeps hair growth phase going in mice.

research Knockdown of FOXA2 Impairs Hair-Inductive Activity of Cultured Human Follicular Keratinocytes

5 citations, October 2020 in “Frontiers in Cell and Developmental Biology”

Reducing FOXA2 in skin cells lowers their ability to grow hair.

research Cholesterol Homeostasis in Hair Follicle Keratinocytes Is Disrupted by Impaired ABCA5 Activity

June 2023 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

Impaired ABCA5 activity disrupts cholesterol balance in hair follicle cells, affecting hair growth.

Nestin as a Marker of Unipotent Epithelial Progenitor Cells Differentiating into Outer Root Sheath Keratinocytes in Embryonic and Adult Hair Follicles

research Nestin as a Marker of Unipotent Epithelial Progenitor Cells Differentiating into Outer Root Sheath Keratinocytes in Embryonic and Adult Hair Follicles

June 2022 in “Research Square (Research Square)”

Nestin-expressing cells turn into a specific type of skin cell in hair follicles during development and in adults.

Nestin as a Marker of Unipotent Epithelial Progenitor Cell Differentiation into Outer Root Sheath Keratinocytes in Embryonic and Adult Hair Follicles

research Nestin as a Marker of Unipotent Epithelial Progenitor Cell Differentiation into Outer Root Sheath Keratinocytes in Embryonic and Adult Hair Follicles

May 2022 in “Research Square (Research Square)”

Nestin marks cells that can become a specific type of skin cell in hair follicles of both developing and adult mice.

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community What supplements or extra dtuff do you guys do for your hair?

in Product 2 upvotes 2 months ago

OP uses multivitamins, collagen, biotin, keratin, omega-3, satin bonnet, dandruff shampoo, oil moisturizer, and sun exposure for hair care. Users suggest adding antioxidants, probiotics, pumpkin seed oil, vitamin D, iron, and dermastamping.

community [27/m] Just a quick entry on my 1 Month experience with Fin/Redensyl/Dermarolling

in Treatment 6 upvotes 2 years ago

NathanHsn shares 1-month experience using Finasteride, Redensyl, and dermarolling for hair loss, noticing small baby hairs and no major side effects. PonyBoyBleach relates, also using Finasteride and dermarolling, and is interested in progress updates.

community Verteporfin and Microneedling

in Treatments 5 months ago

Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.