Knockdown of FOXA2 Impairs Hair-Inductive Activity of Cultured Human Follicular Keratinocytes

October 2020 in “ Frontiers in Cell and Developmental Biology ”

Soon‐Sun Bak, Jung Min Park, Ji Won Oh, Jung Chul Kim, Moon Kyu Kim, Young Kwan Sung

FOXA2 hair-inductive activity outer root sheath ORS follicular keratinocytes small interfering RNA siRNA hair follicles WNT7b hair follicle regeneration transcription factor hair growth hair-inducing cells hair follicle development

Studysummary This study found that the trichogenicity of cultured human outer root sheath follicular keratinocytes decreased with longer cultivation periods and was significantly influenced by the expression of the transcription factor FOXA2.

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