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autoimmune disorder causing patchy hair loss
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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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compound from cruciferous vegetables has some mild effects on DHT
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research Chemically Induced Transformation of Human Dermal Fibroblasts to Hair-Inducing Dermal Papilla-Like Cells
Researchers found a way to turn skin cells into cells that can grow new hair.
research Direct Reprogramming of Human Fibroblasts Into Hair-Inducing Dermal Papilla Cell-Like Cells by a Single Small Molecule
The study investigates a new method to combat hair loss by transforming human fibroblasts into hair-inducing dermal papilla cell-like cells (DPC-LCs) using the small molecule peficitinib. Out of 1,817 FDA-approved compounds screened, peficitinib was found effective in converting fibroblasts from human foreskin and scalp into DPC-LCs. These reprogrammed cells were capable of inducing hair growth and exhibited a molecular profile similar to primary dermal papilla cells. Transcriptome analysis showed that important signaling pathways for hair follicle development, such as Wnt and TGF-β, were enriched in these cells. This method could provide a significant supply of hair-inducing cells, potentially improving treatments for hair loss.
research The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization
The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.
research Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-Assembling Peptide Scaffold
The 3D scaffold helped maintain hair cell traits and could improve hair loss treatments.
research Direct Reprogramming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules
Scientists turned mouse skin cells into hair-inducing cells using chemicals, which could help treat hair loss.
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5 / 1000+ resultscommunity Hair Multiplication Projects in China - Promising clinical trial results on Mice
A breakthrough in hair follicle cultivation using induced pluripotent stem cells (iPSCs) has been achieved, producing large hair follicles suitable for transplantation. Clinical trials for this hair multiplication technology are planned in partnership with Yinguan Biotechnology.
community Do hair follicles ever really "die"? Or does all your front, mid, and crown hair just become vellus?
Hair follicles don't truly die but become severely miniaturized. Treatments like finasteride, dutasteride, and minoxidil can help restore hair by providing nutrients and reducing harmful effects on hair roots.
community My Theory Of Androgenic Alopecia
Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.
community Shiseido filed for this patent in May 2019. Let's get some big brain discussion on this.
The conversation discusses a patent filed by Shiseido for cloning Dermal Papilla (DP) cells to treat hair loss. The method involves using viral vectors to maintain the cells' growth-inducing properties, differing from Replicel's approach with Dermal Sheath Cup (DSC) cells.
community Tretinoin potentially can make hair loss worse ?
Tretinoin may worsen hair loss by inducing premature hair follicle regression. It can be used with minoxidil to increase absorption but should not be used alone.