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GlossaryFOXA2

gene encoding a protein that regulates other genes' activity

FOXA2 is a gene that encodes a transcription factor, which is a protein that helps turn specific genes on or off by binding to nearby DNA. This gene plays a crucial role in the development and function of various tissues, including the liver, pancreas, and lungs. In the context of hair and alopecia, while FOXA2 is not directly linked, understanding transcription factors like FOXA2 can provide insights into the complex genetic regulation involved in hair growth and loss.

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research Knockdown of FOXA2 Impairs Hair-Inductive Activity of Cultured Human Follicular Keratinocytes

5 citations, October 2020 in “Frontiers in Cell and Developmental Biology”

Reducing FOXA2 in skin cells lowers their ability to grow hair.

Faculty Opinions Recommendation of Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

research Faculty Opinions Recommendation of Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

June 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Six new risk spots for early hair loss were found, which also link to Parkinson's disease and lower fertility. Two genes, FOXA2 and HDAC4, could be new treatment targets. Hair loss might also be connected to heart disease, metabolic syndrome, and prostate cancer.

research Finding Bald Spots on Chromosome 20p11

1 citations, February 2009 in “Clinical Genetics”

New genes linked to male pattern baldness were found on chromosome 20p11.

research Genetics of Alopecia

April 2012 in “Encyclopedia of Life Sciences”

Different genes are linked to various types of hair loss.

research Faculty Opinions Recommendation of Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

October 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Six new genes linked to early hair loss were found, which also surprisingly connect to Parkinson's disease and lower fertility.

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community 6 month results on topical min, oral fin, and microneedling

in Progress Pictures 701 upvotes 1 year ago

A user (Majestic-Head3874) who has had successful hair regrowth with the combination of topical minoxidil, oral finasteride and microneedling treatments. People are asking for details about these treatments and Majestic-Head3874 is sharing the regimen they used.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 732 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Verteporfin day 119 update - donor hair regeneration human trial

in Research/Science 146 upvotes 2 years ago

A human trial of verteporfin, a drug that can inhibit wound healing by scarring and promote regeneration of original tissue and hair follicles to provide an unlimited source for hair transplants; people discussed the potential of this drug and how it could be rolled out in mainstream with more doctors getting on board.

community Kintor Phase 2 Results released KX-826 (pyrilutamide)

in Research/Science 449 upvotes 2 years ago

Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemic absorption.