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GlossaryFOXC2

gene involved in tissue development and hair follicle regulation

FOXC2 is a gene that encodes a protein involved in the development and function of various tissues, including the formation of blood vessels and the regulation of fat storage. Mutations in FOXC2 can lead to conditions like lymphedema-distichiasis syndrome, which is characterized by swelling due to fluid retention and the presence of extra eyelashes. This gene also plays a role in hair follicle development and can impact hair growth and health.

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Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures

research Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures

61 citations, September 2010 in “Genomics”

The study found that immune responses disrupt hair growth cycles, causing hair loss in alopecia areata.

research The Browning of White Adipose Tissue: Some Burning Issues

437 citations, August 2014 in “Cell metabolism”

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

research Dental Cell Type Atlas Reveals Stem and Differentiated Cell Types in Mouse and Human Teeth

116 citations, September 2020 in “Nature Communications”

The research identified various cell types in mouse and human teeth, which could help in developing dental regenerative treatments.

research To Grow or Not to Grow: Hair Morphogenesis and Human Genetic Hair Disorders

43 citations, December 2013 in “Seminars in Cell & Developmental Biology”

Genetic mutations can cause hair growth disorders by affecting key genes and signaling pathways.

research Role of Bulge Epidermal Stem Cells and TSLP Signaling in Psoriasis

19 citations, September 2019 in “EMBO molecular medicine”

Blocking TSLP reduces skin inflammation and cell overgrowth in psoriasis.

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community 6 month results on topical min, oral fin, and microneedling

in Progress Pictures 701 upvotes 1 year ago

A user (Majestic-Head3874) who has had successful hair regrowth with the combination of topical minoxidil, oral finasteride and microneedling treatments. People are asking for details about these treatments and Majestic-Head3874 is sharing the regimen they used.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 732 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Verteporfin day 119 update - donor hair regeneration human trial

in Research/Science 146 upvotes 2 years ago

A human trial of verteporfin, a drug that can inhibit wound healing by scarring and promote regeneration of original tissue and hair follicles to provide an unlimited source for hair transplants; people discussed the potential of this drug and how it could be rolled out in mainstream with more doctors getting on board.

community Kintor Phase 2 Results released KX-826 (pyrilutamide)

in Research/Science 449 upvotes 2 years ago

Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemic absorption.