The Browning of White Adipose Tissue: Some Burning Issues

    August 2014 in “ Cell metabolism ”
    Jan Nedergaard, Barbara Cannon
    Image of study
    TLDR Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.
    The document from 2014 explores the concept of "browning" white adipose tissue (WAT) to combat obesity and related diseases like type 2 diabetes. Browning refers to the process where WAT develops characteristics of brown adipose tissue, notably increasing uncoupling protein 1 (UCP1) expression, which leads to higher heat production. The authors propose that browning agents, such as certain foods, drugs, and environmental changes, might stimulate this process. They also suggest that increased heat loss due to changes in insulation, like fur loss, could drive the browning process by activating the sympathetic nervous system. The paper emphasizes the need for browning agents that work without causing heat loss for effective human therapy and calls for thorough evaluations of these agents to confirm their direct browning effects. The document is a perspective piece and does not include specific study data.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community The Big Fat Layer II

      in Research/Science  26 upvotes 4 years ago
      Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

      community The Big Fat Layer / Remedies: Cetirizine

      in Treatment  8 upvotes 4 years ago
      Treating hair loss with various remedies, such as Cetirizine and the Big3 complex (minoxidil, finasteride, and RU58841), which have properties like adipogenic, anti-fibrotic and anti-inflammatory. References to research studies are also included.

      community Injecting stomach fat into the scalp could cure baldness in just six months

      in Update  114 upvotes 6 years ago
      A potential treatment for hair loss that involves injecting fat into the scalp; the role of testosterone and estrogen in thinning fat tissue under the skin; research on using lard to treat androgenic alopecia, as well as PRP + ACELL/amniotic stem cell treatments; and ongoing clinical trials by doctors involved in the study.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 11 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Dutasteride High Libido. How come we don't talk about this?

      in Finasteride/Dutasteride  210 upvotes 8 months ago
      Dutasteride and finasteride can affect libido differently, with some experiencing increased libido and others decreased libido or erectile dysfunction. Dutasteride may increase testosterone levels but can also cause side effects like liver enzyme changes, while topical finasteride may have fewer sexual side effects.

    Similar Research

    5 / 1000+ results