Innovative Approach for Polycystic Ovary Syndrome Treatment: Brown Adipose Tissue

August 2023 in “ MOJ women's health ”

Kulvinder Kochar Kaur, Gautam Allahbadia, Mandeep Singh

Brown Adipose Tissue BAT Polycystic Ovary Syndrome PCOS endocrine action energy balance lipid homeostasis cold stimulation BAT transplantation rutin glucose oxidation triglyceride oxidation metabolic homeostasis brown fat cold exposure metabolic balance

TLDR Brown Adipose Tissue (BAT) could potentially treat Polycystic Ovary Syndrome (PCOS) by controlling energy balance and lipid homeostasis, but more human research is needed.

The narrative review discusses the potential of Brown Adipose Tissue (BAT) in treating Polycystic Ovary Syndrome (PCOS), a disorder affecting 20-25% of women of reproductive age. The review analyzed 100 articles and found that BAT's endocrine action impacts energy balance and lipid homeostasis, which can control PCOS properties. Increasing BAT mass/activity can be effective in treating PCOS through cold stimulation, BAT transplantation, and activation with substances like rutin. BAT can also oxidize glucose and triglycerides from the blood, helping maintain metabolic homeostasis. However, most studies have been conducted in animals, and more research is needed to validate these findings in humans.

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research Update on Polycystic Ovary Syndrome

4 citations , September 2021 in “Clinical and Experimental Reproductive Medicine”

The 2018 guideline for PCOS suggests new diagnostic criteria and treatments, but recognizes the need for more research.

research The Pathogenesis and Treatment of Polycystic Ovary Syndrome: What’s New?

135 citations , April 2017 in “Advances in Clinical and Experimental Medicine”

New treatments for PCOS show promise, including both medication and non-medication options.

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1 citations , February 2017 in “Journal of gynecology and womens health”

The document concluded that more research is needed to understand how estrogen affects the enzyme involved in hirsutism development.

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62 citations , December 2015 in “Clinical Medicine”

Improving insulin sensitivity and weight loss can help manage polycystic ovary syndrome (PCOS).

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1514 citations , January 2012 in “Fertility and sterility”

Experts agree that PCOS affects women's health in complex ways, but more research is needed to understand and treat it effectively.

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991 citations , January 2011 in “Nature Reviews Endocrinology”

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

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926 citations , June 2010 in “BMC Medicine”

Polycystic ovary syndrome is a complex condition that affects women's mental, reproductive, and metabolic health throughout their lives.

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

1540 citations , February 2009 in “Fertility and Sterility”

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.