Brown Adipose Tissue as an Innovative Approach for Polycystic Ovary Syndrome Treatment: A Narrative Review

Brown adipose tissue (BAT) plays a significant role in metabolism and energy expenditure through non-shivering thermogenesis, primarily driven by uncoupling protein 1 (UCP1). This narrative review evaluated the potential role of BAT in treating polycystic ovary syndrome (PCOS) by analyzing 100 selected articles from a total of 250. The review found that BAT can influence glucose and lipid homeostasis, which is crucial for managing PCOS, a complex reproductive and metabolic condition. Studies suggest that increasing BAT mass and activity through methods like cold stimulation, BAT transplantation, and activation with substances such as rutin can be effective in treating PCOS. However, more research is needed before these approaches can be clinically applied.