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    Glossary Lipid Homeostasis

    body's regulation of fat synthesis, storage, and breakdown

    Lipid homeostasis, also known as lipid balance or lipid regulation, refers to the body's ability to maintain a stable internal environment for lipids, which are fats and fat-like substances. This involves the regulation of lipid synthesis, storage, and breakdown to ensure that cells and tissues have the right amount of lipids for energy production, cell membrane structure, and signaling functions. Proper lipid homeostasis is crucial for overall health, as imbalances can lead to conditions such as obesity, cardiovascular disease, and metabolic disorders.

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    1. Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis Cell Reports · 2025 · 5 citations
    2. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation Journal of Allergy and Clinical Immunology · 2019 · 34 citations
    3. Development and homeostasis of the sebaceous gland Seminars in Cell & Developmental Biology · 2012 · 107 citations
    4. Author response: Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ 2017
    5. Decision letter: Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ 2016
    6. Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis Journal of Investigative Dermatology · 2020 · 15 citations
    7. 732 Ceramide synthase 4 controls epidermal lipid composition and barrier function Journal of Investigative Dermatology · 2018
    8. Cholesterol homeostasis: Links to hair follicle biology and hair disorders Experimental Dermatology · 2019 · 25 citations
    9. Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis American Journal of Physiology-endocrinology and Metabolism · 2013 · 14 citations
    10. ZNF750 safeguards upper hair follicle homeostasis to prevent inflammatory skin disease Journal of Investigative Dermatology · 2026
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    Community 1 of 15

    1. Hair Loss & Lipids: Why you have sebderm, folliculitis, LPP, inflammation, etc... Reddit · 18 Mar 2025
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