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    Glossary Lipid Homeostasis

    body's regulation of fat synthesis, storage, and breakdown

    Lipid homeostasis, also known as lipid balance or lipid regulation, refers to the body's ability to maintain a stable internal environment for lipids, which are fats and fat-like substances. This involves the regulation of lipid synthesis, storage, and breakdown to ensure that cells and tissues have the right amount of lipids for energy production, cell membrane structure, and signaling functions. Proper lipid homeostasis is crucial for overall health, as imbalances can lead to conditions such as obesity, cardiovascular disease, and metabolic disorders.

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    1. Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis Cell Reports · 2025 · 5 citations
    2. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation Journal of Allergy and Clinical Immunology · 2019 · 34 citations
    3. Development and homeostasis of the sebaceous gland Seminars in Cell & Developmental Biology · 2012 · 107 citations
    4. Author response: Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ 2017
    5. Decision letter: Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ 2016
    6. Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis Journal of Investigative Dermatology · 2020 · 15 citations
    7. 732 Ceramide synthase 4 controls epidermal lipid composition and barrier function Journal of Investigative Dermatology · 2018
    8. Cholesterol homeostasis: Links to hair follicle biology and hair disorders Experimental Dermatology · 2019 · 25 citations
    9. Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis American Journal of Physiology-endocrinology and Metabolism · 2013 · 14 citations
    10. ZNF750 safeguards upper hair follicle homeostasis to prevent inflammatory skin disease Journal of Investigative Dermatology · 2026
    11. Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium Cell · 2019 · 181 citations
    12. Enhanced therapeutic effects of all-trans retinoic acid nanostructured lipid carrier composite gel drug delivery system for alopecia areata Journal of Nanobiotechnology · 2025
    13. Regulation of Tmem30b-mediated apical membrane homeostasis in auditory outer hair cells is critical for hearing Proceedings of the National Academy of Sciences · 2026
    14. Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations Frontiers in immunology · 2022 · 21 citations
    15. Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions Biological Chemistry · 2008 · 84 citations
    16. Effects of Curcumin on Glycemic Control and Lipid Profile in Polycystic Ovary Syndrome: Systematic Review with Meta-Analysis and Trial Sequential Analysis Nutrients · 2021 · 31 citations
    17. Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells Stem Cell Reports · 2017 · 20 citations
    18. The pattern recognition receptor toll-like receptor 3 regulates skin barrier homeostasis eScholarship (California Digital Library) · 2014
    19. 415 Targeting inflammation and specialized pro-resolving mediators to reinforce barrier function and scalp homeostasis. Journal of Investigative Dermatology · 2022
    20. Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome American journal of human genetics · 2020 · 34 citations
    21. Inactivation of autophagy leads to changes in sebaceous gland morphology and function Experimental dermatology · 2018 · 27 citations
    22. Localisation and regulation of cholesterol transporters in the human hair follicle: mapping changes across the hair cycle Histochemistry and Cell Biology · 2021 · 13 citations
    23. ‘’Brown adipose tissue in the form of innovative approach for polycystic ovary syndrome treatment-still long time to reach clinical arena: a narrative review’’ Advancement in yoga and physical therapy · 2023
    24. Brown adipose tissue in the form of innovative approach for polycystic ovary syndrome treatmentstill long time to reach clinical arena: a narrative review MOJ women's health · 2023
    25. A Rare Case of Keratosis Follicularis Spinulosa Decalvans Affecting a Female Child Clinical dermatology review · 2022
    26. Regulation of the metabolic phenotype of human hepatocytes by glucocorticoids and androgens University of Birmingham Institutional Research Archive (University of Birmingham) · 2016
    27. Dermal white adipose tissue development and metabolism: The role of transcription factor Foxn1 ˜The œFASEB journal · 2023
    28. Adipocytes in Skin Health and Disease Cold Spring Harbor Perspectives in Medicine · 2014 · 77 citations
    29. PPAR‐γ signalling as a key mediator of human hair follicle physiology and pathology Experimental Dermatology · 2019 · 24 citations
    30. The Mixed Lineage Kinase Leucine-Zipper Protein Kinase Exhibits a Differentiation-Associated Localization in Normal Human Skin and Induces Keratinocyte Differentiation upon Overexpression Journal of Investigative Dermatology · 2000 · 17 citations