Inactivation of Autophagy Leads to Changes in Sebaceous Gland Morphology and Function

    July 2018 in “ Experimental dermatology ”
    Heidemarie Rossiter, Gerald Stübiger, Marion Gröger … Erwin Tschachler
    Studysummary This study found that autophagy plays a role in sebaceous gland function and sebum composition control in mice lacking the Atg7 gene in keratinocytes.
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    Research cited in this study 9

    1. Genetically Modified Laboratory Mice with Sebaceous Glands Abnormalities Cellular and Molecular Life Sciences · 2016
    2. Lipid Droplets And Associated Proteins In Sebocytes Experimental Cell Research · 2015
    3. Mechanistic Target of Rapamycin (mTOR) Expression Is Increased in Acne Patients' Skin Experimental Dermatology · 2015
    4. Activation of Nrf2 in Keratinocytes Causes Chloracne-Like Skin Disease in Mice EMBO molecular medicine · 2014
    5. Ligand-Independent Epidermal Growth Factor Receptor Hyperactivation Increases Sebaceous Gland Size and Sebum Secretion in Mice Experimental Dermatology · 2013
    6. Development and Homeostasis of the Sebaceous Gland Seminars in Cell & Developmental Biology · 2012
    7. Epigen Transgenic Mice Develop Enlarged Sebaceous Glands Journal of Investigative Dermatology · 2009
    8. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    9. Abnormal Differentiation of Epidermis in Transgenic Mice Constitutively Expressing Cyclooxygenase-2 in Skin Proceedings of the National Academy of Sciences · 2001

    Related research 1

    1. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989