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GlossarySebocyte Proliferation

increase in oil-producing skin cells' multiplication

Sebocyte proliferation refers to the process by which sebocytes, the cells that make up the sebaceous glands in the skin, multiply and increase in number. These glands produce sebum, an oily substance that helps keep the skin moisturized. An increase in sebocyte proliferation can lead to conditions like acne due to excess sebum production.

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research Deletion of Myelin Protein Zero-Like 3 Increases Sebaceous Gland Size and Sebocyte Proliferation but Reduces Skin Adipose Depots: Can MPZL3 Inhibition Promote Excessive Loss of Lipids via Sebum Hypersecretion?

November 2022 in “Journal of Investigative Dermatology”

Deleting MPZL3 increases skin oil production and reduces body fat.

research MPZL3 Functions as a Negative Regulator of Sebaceous Gland Size and Sebocyte Proliferation

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

MPZL3 protein helps keep sebaceous gland size and cell growth in check.

research Inactivation of Autophagy Leads to Changes in Sebaceous Gland Morphology and Function

27 citations, July 2018 in “Experimental dermatology”

Autophagy is crucial for normal sebaceous gland function and sebum composition.

research The Human Skin as a Hormone Target and an Endocrine Gland

146 citations, January 2004 in “Hormones”

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

research Loss of Keratin 10 Is Accompanied by Increased Sebocyte Proliferation and Differentiation

36 citations, January 2004 in “European journal of cell biology”

Without keratin 10, there's more growth and development of oil-producing skin cells.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 6 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community dht becoming active since the scalp is tight en cause inflammation

in Research/Science 6 upvotes 2 years ago

User discusses tight scalp causing hair loss and suggests treatments like scalp massages, PRP, saw palmetto, and eucapil. They share their experience with saw palmetto and eucapil and consider adding PRP and scalp massages for better results.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 1 year ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.