Polycystic Ovary Syndrome and Oxidative Stress: From Bench to Bedside

    September 2023 in “ International journal of molecular sciences ”
    Natalia Żeber‐Lubecka, Michał Ciebiera, Ewa E. Hennig
    TLDR Oxidative stress worsens PCOS by damaging cells and disrupting metabolism, suggesting antioxidant treatments might help.
    The document "Polycystic Ovary Syndrome and Oxidative Stress—From Bench to Bedside" explores the relationship between oxidative stress (OS) and PCOS, highlighting how mitochondrial dysfunction and excessive reactive oxygen species (ROS) production contribute to the condition. OS negatively impacts ovarian follicles, disrupts follicular development, and impairs fertility. It also exacerbates insulin resistance (IR) and inflammation, creating a feedback loop that increases ROS production. The review discusses potential therapeutic interventions, including antioxidants like vitamins C and E, N-acetylcysteine (NAC), and selenium, which show promise in managing PCOS by reducing OS and improving insulin sensitivity. The study emphasizes the need for further research to understand the underlying mechanisms and develop effective treatments.
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