Polycystic Ovary Syndrome and Oxidative Stress: From Bench to Bedside

    September 2023 in “ International journal of molecular sciences ”
    Natalia Żeber‐Lubecka, Michał Ciebiera, Ewa E. Hennig
    TLDR Oxidative stress worsens PCOS by damaging cells and disrupting metabolism, suggesting antioxidant treatments might help.
    The document "Polycystic Ovary Syndrome and Oxidative Stress—From Bench to Bedside" explores the relationship between oxidative stress (OS) and PCOS, highlighting how mitochondrial dysfunction and excessive reactive oxygen species (ROS) production contribute to the condition. OS negatively impacts ovarian follicles, disrupts follicular development, and impairs fertility. It also exacerbates insulin resistance (IR) and inflammation, creating a feedback loop that increases ROS production. The review discusses potential therapeutic interventions, including antioxidants like vitamins C and E, N-acetylcysteine (NAC), and selenium, which show promise in managing PCOS by reducing OS and improving insulin sensitivity. The study emphasizes the need for further research to understand the underlying mechanisms and develop effective treatments.
    Discuss this study in the Community →

    Research cited in this study

    9 / 9 results

    Related Community Posts Join

    6 / 12 results

      community How does hair loss and recovery work?

      in Chat  12 upvotes 3 months ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

      community C’est terrible - at my wits end

      in Female  449 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  53 upvotes 1 year ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community Why balding gets worse in every generation?

      in Chat  81 upvotes 6 months ago
      Balding seems to worsen with each generation, possibly due to stress, diet, and environmental factors. The user started treatments like Minoxidil and finasteride.

    Similar Research

    5 / 1000+ results