Hyperandrogenism in Polycystic Ovarian Syndrome and Role of CYP Gene Variants: A Review

    November 2019 in “ Egyptian Journal of Medical Human Genetics ”
    Sairish Ashraf, Mudasar Nabi, Shabhat Rasool … Shajrul Amin
    Studysummary This review discusses the role of CYP gene polymorphisms in exacerbating hyperandrogenism in women with PCOS and reports no clinical results; further validation of this hypothesis is needed.
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    Research cited in this study 16

    1. Elevated Fasting Insulin Is Associated With Cardiovascular and Metabolic Risk in Women With Polycystic Ovary Syndrome Diabetes and Metabolic Syndrome: Clinical Research and Reviews · 2019
    2. Cutaneous Manifestations of Polycystic Ovary Syndrome: A Cross-Sectional Clinical Study Indian Dermatology Online Journal · 2017
    3. Hirsutism in Polycystic Ovary Syndrome: Pathophysiology and Management Current pharmaceutical design · 2016
    4. Androgen Profile Through Life in Women With Polycystic Ovary Syndrome: A Nordic Multicenter Collaboration Study The Journal of Clinical Endocrinology and Metabolism · 2015
    5. Therapy of Endocrine Disease: Treatment of Hirsutism in Polycystic Ovary Syndrome European journal of endocrinology · 2013
    6. Polycystic Ovary Syndrome: Etiology, Pathogenesis, and Diagnosis Nature Reviews Endocrinology · 2011
    7. Specific Dermatologic Features of Polycystic Ovary Syndrome and Its Association with Biochemical Markers of Metabolic Syndrome and Hyperandrogenism Acta Obstetricia et Gynecologica Scandinavica · 2010
    8. The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report Fertility and Sterility · 2008
    9. Dermatologic Manifestations of Polycystic Ovary Syndrome American Journal of Clinical Dermatology · 2007
    10. Low Sex Hormone-Binding Globulin Is Associated With Low High-Density Lipoprotein Cholesterol And Metabolic Syndrome In Women With Polycystic Ovary Syndrome Human Reproduction · 2006
    11. Fetal Programming of Polycystic Ovary Syndrome by Androgen Excess: Evidence from Experimental, Clinical, and Genetic Association Studies The Journal of Clinical Endocrinology and Metabolism · 2006
    12. Relative Prevalence of Different Androgen Excess Disorders in 950 Women Referred Because of Clinical Hyperandrogenism The Journal of Clinical Endocrinology and Metabolism · 2006
    13. Health Care-Related Economic Burden of Polycystic Ovary Syndrome During the Reproductive Life Span The Journal of Clinical Endocrinology and Metabolism · 2005
    14. Androgen Excess in Women: Experience with Over 1000 Consecutive Patients The Journal of Clinical Endocrinology and Metabolism · 2004
    15. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS) Human Reproduction · 2003
    16. Adult Polycystic Ovary Syndrome Begins in Childhood Best Practice & Research Clinical Endocrinology & Metabolism · 2002

    Related research 1

    1. Shorter CAG Repeats in the Androgen Receptor Gene May Enhance Hyperandrogenicity in Polycystic Ovary Syndrome Gynecological Endocrinology · 2008