Hyperandrogenism in Polycystic Ovarian Syndrome and Role of CYP Gene Variants: A Review

    Sairish Ashraf, Mudasar Nabi, Shabhat Rasool, Fouzia Rashid, Shajrul Amin
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    TLDR Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.
    The 2019 review by Ashraf et al. focused on the role of genetic factors, specifically cytochrome P450 (CYP) gene variants, in the development of hyperandrogenism in polycystic ovary syndrome (PCOS). PCOS is a complex endocrine disorder characterized by anovulation, hyperandrogenism, and polycystic ovaries, with clinical manifestations such as hirsutism, acne, and alopecia. The review discussed how polymorphisms in CYP genes, which are involved in steroidogenesis, might contribute to the excessive androgen production seen in PCOS. It highlighted the need for further research to clarify the genetic basis of PCOS, given the inconclusive results from various studies due to factors like diagnostic criteria, sample sizes, ethnic diversity, and environmental influences. The review did not provide specific numbers of participants from the studies referenced, as it was a general literature review.
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