Elevated Fasting Insulin Is Associated With Cardiovascular and Metabolic Risk in Women With Polycystic Ovary Syndrome
May 2019
in “
Diabetes and Metabolic Syndrome: Clinical Research and Reviews
”
alopecia acne amenorrhea acanthosis nigricans obesity hyperandrogenism polycystic ovary syndrome PCOS fasting insulin BMI WHR FAI LH:FSH ratio HOMA QUICKI HOMA-IR WHtR LAP hair loss insulin resistance body mass index waist-hip ratio free androgen index homeostatic model assessment quantitative insulin sensitivity check index waist-height ratio lipid accumulation product
TLDR High fasting insulin levels in women with PCOS are linked to a higher risk of heart and metabolic problems.
The study, involving 349 women (249 with PCOS and 100 healthy controls), found that elevated fasting insulin levels in women with PCOS were significantly associated with a range of cardiovascular and metabolic risk factors. Women with PCOS had higher fasting insulin, BMI, WHR, FAI, LH:FSH ratio, HOMA, and QUICKI compared to controls. Higher fasting insulin levels in PCOS patients were correlated with increased BMI, BAI, LAP, HOMA-IR, QUICKI, and FAI. The study also categorized PCOS patients based on fasting insulin levels and found that those with higher levels had a greater prevalence of acne, alopecia, amenorrhea, acanthosis nigricans, and obesity, as well as higher cardiovascular-metabolic risk factors like BMI, WHtR, HOMA IR, FAI, and LAP. The conclusion was that fasting insulin is a key determinant in the pathogenesis of obesity and hyperandrogenism in PCOS and is linked to an increased risk of cardiovascular and metabolic disorders.
