AKT2 Gene Polymorphisms, sRANKL/OPG and Hormone Measurements in Polycystic Ovarian Syndrome Women
January 2017
in “
Clinical & medical biochemistry
”
TLDR Certain gene variations in AKT2 are more common in women with PCOS and are linked to higher levels of specific hormones and symptoms.
In a 2017 study involving 60 Greek Caucasian women with Polycystic Ovarian Syndrome (PCOS) and 30 healthy controls, researchers found significant differences in serum levels of sRANKL, DHEAS, testosterone, 17-OH progesterone, E2, SHBG, and prolactin between the two groups. The study also identified a significant association between the AKT2 gene polymorphism rs2304188 and PCOS, with the minor allele being more frequent in PCOS patients and linked to higher levels of DHEAS, 17-OH progesterone, and hirsutism. Additionally, the presence of two specific AKT2 gene polymorphisms (rs8100018 in combination with either rs11671439 or rs2304188) was exclusively found in PCOS patients, suggesting a strong predictive value for the condition. The study highlights the potential relevance of AKT2 gene polymorphisms in PCOS and its symptoms, but also acknowledges the need for further research with larger populations due to the small sample size of participants with the polymorphism.
