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GlossaryDehydroepiandrosterone (DHEA)

hormone produced by adrenal glands, precursor to sex hormones

Dehydroepiandrosterone (DHEA) is a hormone produced by the adrenal glands, which are located above the kidneys. It serves as a precursor to male and female sex hormones, including testosterone and estrogen. DHEA levels naturally decline with age and are sometimes supplemented to address various health issues, such as adrenal insufficiency, depression, and certain autoimmune diseases.

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Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?

research Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?

9 citations , February 2020 in “International Journal of Endocrinology”

Some men with early hair loss may have a male version of PCOS, affecting hormones and increasing health risks.

research Elevated DHEAS and Acute Hair Loss in an Adult Male with Trichorhinophalangeal Syndrome Type 1: A Case of Male PCOS

November 2022 in “Journal of the Endocrine Society”

A 21-year-old male with a rare genetic disorder experienced sudden hair loss and high DHEAS levels, likely due to a condition similar to PCOS, usually seen in women.

research The Serum Evaluation of Sex Hormones Including DHEAs, DHT, Testosterone in Oral Lichen Planus Patients

1 citations , May 2025 in “Scientific Reports”

research The Serum Evaluation of Sex Hormones Including DHEAs, DHT, Testosterone in Oral Lichen Planus Patients

April 2025

Receiver Operating Characteristic Analysis of the Performance of Basal Serum Hormone Profiles for the Diagnosis of Polycystic Ovary Syndrome in Epidemiological Studies

research Receiver Operating Characteristic Analysis of the Performance of Basal Serum Hormone Profiles for the Diagnosis of Polycystic Ovary Syndrome in Epidemiological Studies

66 citations , November 2001 in “European journal of endocrinology”

Low SHBG and high FAI, FT, and DHEAS levels are effective in identifying PCOS.

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community Hair loss - Blood work (High DHEAS)

in Research/Science 8 upvotes 3 years ago

A user has been taking finasteride for 5 months with no improvement in diffuse hair loss and suspects high levels of prolactin, cortisol, progesterone, and DHEAS, as well as iron, might be contributing to the issue. They are also taking vitamin D to address a deficiency.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 2 years ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community 31M - major hair shedding after weight loss + stopping vitamins — help!

in Minoxidil 4 upvotes 5 months ago

A 31-year-old male experienced hair shedding after rapid weight loss and stopping vitamins, despite using minoxidil and other supplements. He is considering Saw Palmetto and Pumpkin Seed Oil instead of finasteride due to trying for kids, and is concerned about high ferritin and DHEAS levels.

community Dutasteride is amazing even for women with FAGA!

in Female 151 upvotes 2 months ago

Dutasteride significantly improved hair health and reduced shedding for a woman with PCOS and hyperandrogenism, without causing depression or anxiety, unlike finasteride. Dutasteride also helped with PMDD symptoms and had no side effects, though it changed hair texture.

community My numbers seem completely off. 24M (Diffused thinning)

in Chat 2 upvotes 3 months ago

A 24-year-old male experiencing diffused thinning discusses his DHT levels and hair density issues. He has not used finasteride or dutasteride and is considering AR inhibitors.

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