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GlossaryDehydroepiandrosterone (DHEA)

hormone produced by adrenal glands, precursor to sex hormones

Dehydroepiandrosterone (DHEA) is a hormone produced by the adrenal glands, which are located above the kidneys. It serves as a precursor to male and female sex hormones, including testosterone and estrogen. DHEA levels naturally decline with age and are sometimes supplemented to address various health issues, such as adrenal insufficiency, depression, and certain autoimmune diseases.

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Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?

research Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?

9 citations, February 2020 in “International Journal of Endocrinology”

Some men with early hair loss may have a male version of PCOS, affecting hormones and increasing health risks.

research Elevated DHEAS and Acute Hair Loss in an Adult Male with Trichorhinophalangeal Syndrome Type 1: A Case of Male PCOS

November 2022 in “Journal of the Endocrine Society”

A 21-year-old male with a rare genetic disorder experienced sudden hair loss and high DHEAS levels, likely due to a condition similar to PCOS, usually seen in women.

Receiver Operating Characteristic Analysis of the Performance of Basal Serum Hormone Profiles for the Diagnosis of Polycystic Ovary Syndrome in Epidemiological Studies

research Receiver Operating Characteristic Analysis of the Performance of Basal Serum Hormone Profiles for the Diagnosis of Polycystic Ovary Syndrome in Epidemiological Studies

66 citations, November 2001 in “European journal of endocrinology”

Low SHBG and high FAI, FT, and DHEAS levels are effective in identifying PCOS.

Elevated Dehydroepiandrosterone Sulfate Levels as the Reproductive Phenotype in the Brothers of Women with Polycystic Ovary Syndrome

research Elevated Dehydroepiandrosterone Sulfate Levels as the Reproductive Phenotype in the Brothers of Women with Polycystic Ovary Syndrome

27 citations, May 2002 in “The Journal of Clinical Endocrinology & Metabolism”

Brothers of women with PCOS tend to have higher levels of a hormone called DHEAS, indicating a possible genetic link.

research Bone Mineral Density in Hyperandrogenic Amenorrhea

22 citations, June 1993 in “Calcified Tissue International”

Women with hyperandrogenic amenorrhea have similar bone density to healthy women but lower than androgenized women without amenorrhea, and high DHEAS levels might affect bone density.

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community Hair loss - Blood work (High DHEAS)

in Research/Science 9 upvotes 2 years ago

A user has been taking finasteride for 5 months with no improvement in diffuse hair loss and suspects high levels of prolactin, cortisol, progesterone, and DHEAS, as well as iron, might be contributing to the issue. They are also taking vitamin D to address a deficiency.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 1 year ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community How does hair loss and recovery work?

in Chat 12 upvotes 2 months ago

Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community Going to a cosmetic derm soon. What should I ask for?

in Female 3 upvotes 1 year ago

Female, 28, losing hair since 17, using 200mg Spiro. Tried Minoxidil and ketoconazole with limited success, considering oral minox and seeking alternative treatments from cosmetic dermatologist.

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