Bone Mineral Density in Hyperandrogenic Amenorrhea

    June 1993 in “ Calcified Tissue International ”
    Janez Preželj, A Kocijancic
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    TLDR Women with hyperandrogenic amenorrhea have similar bone density to healthy women but lower than androgenized women without amenorrhea, and high DHEAS levels might affect bone density.
    Between October 1991 and February 1992, Janez Preželj and Andreja Kocijančič studied bone mineral density (BMD) in 61 women, including 9 with hyperandrogenic amenorrhea (group A), 30 nonamenorrheic androgenized women (group B), and 22 healthy controls. They found that the BMD in group A (1.023 ± 0.045 g/cm²) was similar to that of the controls (1.047 ± 0.083 g/cm²) but significantly lower than that of group B (1.099 ± 0.085 g/cm²). A significant negative correlation was observed between BMD and serum dehydroepiandrosterone sulfate (DHEAS) levels (r = -0.45). The study concluded that hyperandrogenic amenorrhea may protect against osteopenia, unlike other forms of amenorrhea, but high DHEAS levels could indicate other factors affecting BMD, warranting further investigation.
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