Epigenetic Mechanism of Gtl2-miRNAs Causes the Primitive Sheep Characteristics Found in Purebred Merino Sheep

    October 2023 in “ Cell & bioscience ”
    Jiankui Wang, Guoying Hua, Jianfei Chen … Xuemei Deng
    Studysummary This study identified a primitive coarse wool characteristic in Merino sheep that enhances environmental adaptability and fine wool yield without reducing quality, suggesting that epigenetic mechanisms, particularly involving the imprinted Gtl2-miRNAs locus, regulate this advantageous trait.
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    Research cited in this study 4

    1. Genome-Wide DNA Methylation and Transcriptome Analyses Reveal the Key Gene for Wool Type Variation in Sheep Journal of Animal Science and Biotechnology · 2023
    2. Integrated miRNA-mRNA Analysis Reveals Regulatory Pathways Underlying the Curly Fleece Trait in Chinese Tan Sheep BMC genomics · 2018
    3. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    4. Transcriptional Regulation Analysis and the Potential Transcription Regulator Site in the Extended KAP6.1 Promoter in Sheep Molecular Biology Reports · 2014