Integrated miRNA-mRNA Analysis Reveals Regulatory Pathways Underlying the Curly Fleece Trait in Chinese Tan Sheep

    May 2018 in “ BMC genomics ”
    Yufang Liu, J. Zhang, Qiao Xu, Xiaolong Kang, Kejun Wang, Keliang Wu, Meiying Fang
    TLDR Researchers found genes and microRNAs that control curly fleece in Chinese Tan sheep.
    The study investigated the genetic basis of the curly fleece trait in Chinese Tan sheep by integrating miRNA and mRNA analysis. Researchers identified 49 differentially expressed miRNAs and 36 miRNA-mRNA pairs, revealing key regulatory pathways such as MAPK, WNT, and AMPK signaling involved in hair follicle development and keratinocyte differentiation. The findings, including the inhibition of KRT83 expression by miR-432, provided insights into the molecular mechanisms underlying the curly fleece phenotype, which could inform breeding programs and enhance understanding of hair growth in humans.
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