Autophagy Dysfunction: The Kernel of Hair Loss?

May 2024 in “ Clinical Cosmetic and Investigational Dermatology ”

Xu Jin, Xiuzu Song

autophagy mitophagy hair follicle cycles hair follicle stem cells dermal papilla cells cellular metabolic functions regulatory mechanisms therapeutic strategies

Studysummary In this study, researchers reviewed the roles of autophagy and mitophagy in hair follicle cycles, exploring their potential links to hair loss and investigating how manipulating these pathways might offer new therapeutic strategies.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The paper "Autophagy Dysfunction: The Kernel of Hair Loss?" investigates the role of autophagy in hair loss conditions like androgenetic alopecia (AGA) and alopecia areata (AA). Autophagy, essential for cellular health, is particularly active during the anagen phase of the hair cycle and crucial for hair follicle stem cell activation. Dysfunction in autophagy can lead to premature hair cycle transitions and hair loss. The study highlights that targeting autophagy pathways could offer new therapeutic strategies for treating alopecia. Treatments like human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) and autophagy promoters like spermidine show potential in mitigating hair loss by enhancing autophagy. The review underscores the need for further research to fully understand the mechanisms and develop targeted treatments for hair loss.

View this study on dovepress.com →

Discuss this study in the Community →

Research cited in this study

81 / 81 results

Bioinspired Engineering of ADSC Nanovesicles in Thermosensitive Hydrogel to Enhance Autophagy of Dermal Papilla Cells for Androgenetic Alopecia Treatment

research Bioinspired Engineering of ADSC Nanovesicles in Thermosensitive Hydrogel to Enhance Autophagy of Dermal Papilla Cells for Androgenetic Alopecia Treatment

March 2024 in “Bioactive Materials”

This study found that modifying adipose-derived stem cells to overexpress the adhesion protein JAM-A increased the adhesion and resilience of dermal papilla cells in the context of androgenic alopecia, potentially facilitating hair regrowth despite challenges such as damage from dihydrotestosterone and macrophages.

research Autophagy Induces Hair Follicle Stem Cell Activation and Hair Follicle Regeneration by Regulating Glycolysis

January 2024

This study found that activating autophagy in hair follicle stem cells can promote hair growth by shifting their metabolism to glycolysis, while inhibiting it led to delayed hair cycle progression.

research Activating Autophagy Promotes Skin Regeneration Induced by Mechanical Stretch During Tissue Expansion

January 2024 in “Burns and trauma”

In a rat scalp expansion model, this study found that activating autophagy with rapamycin enhanced skin regeneration during tissue expansion by increasing expanded skin area, epidermis and dermis thicknesses, cell proliferation, angiogenesis, and other regenerative factors, whereas blocking autophagy reversed these effects.

research Real-World Treatment Patterns Among Patients With Alopecia Areata in the USA: A Retrospective Claims Analysis

1 citations , August 2023 in “Acta dermato-venereologica”

This study found that corticosteroids were the most common treatments for alopecia areata in the USA, but the substantial disease burden suggests a need for more effective options.

research Autophagy Critically Controls Skin Inflammation and Apoptosis-Induced Stem Cell Activation

2 citations , August 2023 in “Autophagy”

In this study, researchers found that keratinocyte-specific deletion of the autophagy mediator Atg16l1 in mice heightened skin inflammation and cancer responses, altered hair follicle stem cell activity, and sensitized keratinocytes to cell death.

Therapeutic Effects of Topical Cetirizine in the Treatment of Female Pattern Hair Loss: A Randomized Controlled Noninferiority Trial

research Therapeutic Effects of Topical Cetirizine in the Treatment of Female Pattern Hair Loss: A Randomized Controlled Noninferiority Trial

August 2023 in “Expert Review of Clinical Pharmacology”

This study found that while both topical cetirizine and minoxidil improved female pattern hair loss, minoxidil was significantly more effective in increasing hair density.

research Autophagy Controls the Protein Composition of Hair Shafts

2 citations , July 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that blocking autophagy in Atg7-deficient mouse hair keratinocytes altered the molecular composition of hair shafts by increasing the abundance of proteins involved in protein turnover while keratins remained unchanged, highlighting autophagy's role in reducing non-cytoskeletal protein concentrations in hair.

research Overview of the Circadian Clock in the Hair Follicle Cycle

July 2023 in “Biomolecules”

In this review, the authors discussed how the circadian clock influences hair follicle regeneration by regulating metabolism, suggesting potential new targets for hair loss treatments.

research Oxidative Stress and Alopecia Areata

3 citations , June 2023 in “Frontiers in medicine”

This review discusses the association between oxidative stress and alopecia areata while proposing antioxidants as a potential supplementary therapy, but it reports no new clinical results.

research Novel Recombinant R-Spondin1 Promotes Hair Regeneration by Targeting the Wnt/β-Catenin Signaling Pathway

8 citations , June 2023 in “Acta Biochimica et Biophysica Sinica”

In this study, a subcutaneous injection of recombinant RSPO1 was found to activate hair follicle stem cells and enhance hair regeneration in mice by stimulating the Wnt/β-catenin signaling pathway, suggesting its potential as a treatment for hair loss.

research The Crosstalk Between PTEN-Induced Kinase 1-Mediated Mitophagy and the Inflammasome in the Pathogenesis of Alopecia Areata

6 citations , June 2023 in “Experimental Dermatology”

In this study, researchers found that inducing mitophagy can alleviate NLRP3 inflammasome activation in outer root sheath cells under conditions of mitochondrial stress, suggesting that targeting mitophagy and inflammasome interactions may offer new therapeutic approaches for alopecia areata.

research Male Pattern Hair Loss: Can Developmental Origins Explain the Pattern?

May 2023 in “Experimental Dermatology”

In this viewpoint, researchers discussed the possible role of the developmental origin of scalp dermis in influencing the specific pattern of hair follicle miniaturization seen in male pattern hair loss, noting that frontal follicles are more susceptible while occipital follicles remain largely terminal.

research Androgenetic Alopecia: Therapy Update

May 2023 in “Drugs”

This comprehensive review analyzes androgenetic alopecia treatments, discussing the mechanisms, costs, efficacy, and safety of FDA-approved drugs like minoxidil and finasteride, as well as newer non-FDA-approved options that have shown effectiveness across various studies.

research Novel Potential Therapeutic Targets of Alopecia Areata

1 citations , April 2023 in “Frontiers in Immunology”

This review explored recent research on the immune mechanisms and potential therapeutic targets for alopecia areata, highlighting the roles of immune-related cells, autocrine and paracrine signaling, as well as factors like adipose-derived stem cells and gut microbiota in disease pathogenesis.

research Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway

March 2023 in “International Journal of Molecular Sciences”

This study found that exosomes from adipose mesenchymal stromal cells, particularly those carrying miR-122-5p, may enhance hair follicle regeneration in androgenic alopecia by targeting the TGF-β/SMAD3 axis.

research Trends in Prevalence and Incidence of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Among Adults and Children in a US Employer-Sponsored Insured Population

75 citations , March 2023 in “JAMA Dermatology”

This study reported that the prevalence of alopecia areata in the US slightly increased from 0.199% to 0.222% between 2016 and 2019, with higher rates observed in women and adults.

research Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production

2 citations , February 2023 in “International journal of molecular sciences”

This study identified that copper depletion in dermal papilla cells reduced hair growth by boosting ROS levels, but ROS scavengers like NAC and ascorbic acid partially alleviated this effect.

research Induction of Autophagy Improves Skin and Hair Conditions in Dogs with Underlying Diseases

1 citations , January 2023 in “Frontiers in veterinary science”

This study found that treatment with a synthesized autophagy inducer improved skin barrier function and hair damage in dogs with atopic dermatitis or hyperadrenocorticism by reducing pro-inflammatory cytokines.

research Hair Follicles as a Critical Model for Monitoring the Circadian Clock

5 citations , January 2023 in “International Journal of Molecular Sciences”

This review discusses the expression of circadian genes in hair follicles and their potential for monitoring circadian-rhythm-related conditions, reporting no clinical results; the authors suggest combining hair sampling with other assessments for better insight.

research Alopecia Areata: A Review of the Role of Oxidative Stress, Possible Biomarkers, and Potential Novel Therapeutic Approaches

15 citations , January 2023 in “Antioxidants”

This review discusses oxidative stress in alopecia areata pathogenesis and potential treatment strategies, reporting no new clinical results but suggesting biomarkers for oxidative stress and discussing JAK inhibitors as promising options.

research Red Organic Light-Emitting Diodes Based Photobiomodulation Therapy Enabling Prominent Hair Growth

18 citations , January 2023 in “Nano Research”

This study found that red OLED irradiation can significantly promote hair regrowth in mice, increasing hair length by 1.5 times and hair regrowth area by over 3 times after 20 days of treatment.

research The AR/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia

2 citations , January 2023 in “International Journal of Biological Sciences”

In this study, miR-221 was identified as a key factor in androgenetic alopecia pathogenesis due to its role in suppressing hair growth by interacting with androgen receptors and affecting related pathways.

research Limonin, a Component of Immature Citrus Fruits, Activates Anagen Signaling in Dermal Papilla Cells

3 citations , December 2022 in “Nutrients”

This study found that limonin may promote hair growth by enhancing anagen signaling through autophagy activation in rat dermal papilla cells, suggesting its potential as a natural treatment for hair loss.

Ginsenoside Re Prevents 3-Methyladenine-Induced Catagen Phase Acceleration by Regulating Wnt/Beta-Catenin Signaling in Human Dermal Papilla Cells

research Ginsenoside Re Prevents 3-Methyladenine-Induced Catagen Phase Acceleration by Regulating Wnt/Beta-Catenin Signaling in Human Dermal Papilla Cells

5 citations , November 2022 in “Journal of Ginseng Research/Journal of ginseng research”

This study investigated the role of autophagy in human dermal papilla cells and found that inhibiting autophagy accelerates the catagen phase by reducing Wnt/β-catenin signaling. Furthermore, adding ginsenoside Re appears to restore autophagy, suggesting potential benefits for mitigating hair loss linked to autophagy inhibition.

An Integrative Analysis of the LncRNA-MiRNA-mRNA Competitive Endogenous RNA Network Reveals Potential Mechanisms in the Murine Hair Follicle Cycle

research An Integrative Analysis of the LncRNA-MiRNA-mRNA Competitive Endogenous RNA Network Reveals Potential Mechanisms in the Murine Hair Follicle Cycle

October 2022 in “Frontiers in Genetics”

This study found that miRNAs increase and target mRNAs and lncRNAs decrease from the anagen to telogen phase in mouse hair follicles, and these ceRNA networks may play a role in hair follicle cycling.

research Autophagy: Guardian of Skin Barrier

8 citations , July 2022 in “Biomedicines”

This review discusses the role of autophagy in skin cells and its potential implications for treating immune-related skin diseases, reporting no new clinical results.

research Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State

25 citations , June 2022 in “Developmental cell”

In this study, Hedgehog signaling in dermal papilla fibroblasts was found to accelerate hair growth and induce follicle multiplication in mice via the SCUBE3/TGF-β pathway, with some effects observed in human scalp hair follicles.

research 3D Spheroid Human Dermal Papilla Cell as an Effective Model for the Screening of Hair Growth Promoting Compounds: Examples of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid (TCQA)

2 citations , June 2022 in “Cells”

The study found that growing dermal papilla cells in 3D spheroids enhances their activity with hair growth-promoting agents, such as minoxidil and TCQA, compared to traditional 2D cultures.

research Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging

7 citations , May 2022 in “Frontiers in Cell and Developmental Biology”

This review discusses the molecular mechanisms driving hair follicle degeneration in skin aging and emphasizes the role of the tissue microenvironment on stem cell function, but reports no new research findings.

research Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles

21 citations , May 2022 in “Frontiers in Cell and Developmental Biology”

This review covers the structure, development, cycle, and molecular regulation of hair follicles but does not report new results, aiming to offer insights for addressing hair follicle-related diseases.

5-Bromo-3,4-Dihydroxybenzaldehyde Promotes Hair Growth Through Activation of Wnt/β-Catenin and Autophagy Pathways and Inhibition of TGF-β Pathways in Dermal Papilla Cells

research 5-Bromo-3,4-Dihydroxybenzaldehyde Promotes Hair Growth Through Activation of Wnt/β-Catenin and Autophagy Pathways and Inhibition of TGF-β Pathways in Dermal Papilla Cells

7 citations , March 2022 in “Molecules”

This study found that 5-bromo-3,4-dihydroxybenzaldehyde (BDB) promoted hair growth in rat vibrissa follicles by activating Wnt/β-catenin and autophagy pathways and inhibiting the TGF-β pathway in dermal papilla cells.

Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

research Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

14 citations , March 2022 in “Journal of Biomedical Science”

In this study, Cyanidin 3-O-arabinoside was found to protect against DHT-induced dermal papilla cell senescence and mitochondrial dysfunction in androgenetic alopecia, restoring hair growth in mouse models.

research The Associated Burden of Mental Health Conditions in Alopecia Areata: A Population-Based Study in UK Primary Care

20 citations , February 2022 in “British Journal of Dermatology”

This study found that people with alopecia areata have higher rates of depression and anxiety, leading to increased mental health treatment burden, more time off work, and higher unemployment compared to the general population.

research Observations Suggesting a Contribution of Altered Dermal Papilla Mitochondrial Function to Androgenetic Alopecia

4 citations , February 2022 in “Experimental Dermatology”

This study found that mitochondrial dysfunction and higher oxidative stress in balding dermal papilla cells may contribute to androgenetic alopecia, with antioxidants potentially improving metabolite uptake.

research Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management

290 citations , August 2021 in “Clinical Reviews in Allergy & Immunology”

JAK inhibitors show promise for treating alopecia areata, but more research is needed.

research Understanding Causes of Hair Loss in Women

4 citations , May 2021 in “Dermatologic Clinics”

This article reviews advancements in hair transplantation, highlighting robotic and follicular unit techniques, and discusses adjuvant modalities like platelet-rich plasma, lasers, and stem cells without reporting new clinical results.

research Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss

33 citations , February 2021 in “Journal of Medicinal Chemistry”

This study found that novel MPC inhibitor analogues with specific chemical modifications promoted significant hair growth in shaved mice when applied topically.

research Myristoleic Acid Promotes Anagen Signaling by Autophagy Through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells

8 citations , February 2021 in “Biomolecules & therapeutics”

This study found that myristoleic acid promotes dermal papilla cell proliferation and anagen signaling through autophagy, cell cycle progression, and activation of the Wnt/β-catenin and ERK pathways.

research Alopecia in Harlequin Mutant Mice Is Associated with Reduced AIF Protein Levels and Expression of Retroviral Elements

4 citations , December 2020 in “Mammalian genome”

This study found that pelage abnormalities in Harlequin mutant mice are linked to severe AIF deficiency and associated with altered expression of genes related to hair structure.

research Common Causes of Hair Loss: Clinical Manifestations, Trichoscopy, and Therapy

47 citations , December 2020 in “Journal of the European Academy of Dermatology and Venereology”

This article reviews the classification, diagnosis, and management of hair disorders, emphasizing the role of trichoscopy and early diagnosis for effective treatment but reports no new clinical findings.

Impairment of Autophagy May Be Associated with Follicular Miniaturization in Androgenetic Alopecia by Inducing Premature Catagen

research Impairment of Autophagy May Be Associated with Follicular Miniaturization in Androgenetic Alopecia by Inducing Premature Catagen

4 citations , December 2020 in “Journal of Dermatology”

This study suggests that impaired autophagy may be a potential mechanism contributing to androgenetic alopecia, as observed in miniaturized hair follicles from balding scalps.

research Novel Complex of Cosmetic Ingredients with Promising Action in Preventing Hair Loss and Follicular Aging Through Mechanism Involving Enrichment of WNT/Signaling, Mitochondrial Activity, and Stem Cells Maintenance

8 citations , November 2020 in “Journal of Cosmetic Dermatology”

This preclinical study observed that a nanoencapsulated ingredient complex, AcPi, may prevent hair follicle aging and hair loss by reducing oxidative stress, enhancing mitochondrial activity and WNT/β-catenin signaling, and controlling androgenic metabolism when tested on human scalp cultures.

research Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway

25 citations , September 2020 in “Molecules”

In this study, quercitrin was reported to promote hair growth and cell viability in cultured human dermal papilla cells by enhancing cellular energy metabolism and growth factor production via MAPK/CREB signaling.

Comparison of Mitochondrial Transplantation Using a Stamp-Type Multineedle Injector and Platelet-Rich Plasma Therapy for Hair Aging in Naturally Aging Mice

research Comparison of Mitochondrial Transplantation Using a Stamp-Type Multineedle Injector and Platelet-Rich Plasma Therapy for Hair Aging in Naturally Aging Mice

9 citations , July 2020 in “Biomedicine & Pharmacotherapy”

This study found that Pep-1-mediated mitochondrial transplantation was as effective as PRP therapy in restoring hair loss related to aging in mice, with distinct improvements in hair and skin-related measures.

research Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata

134 citations , July 2020 in “Experimental dermatology”

This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.

Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells

research Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells

15 citations , May 2020 in “BMC complementary medicine and therapies”

This study found that Polygonum multiflorum extract may promote hair growth by increasing anagen duration and activating dermal papilla cells in human hair follicles, as observed in cultured cell models.

research Deficiency of Crif1 in Hair Follicle Stem Cells Retards Hair Growth Cycle in Adult Mice

10 citations , April 2020 in “PloS one”

This study found that mitochondrial dysfunction due to Crif1 deficiency in hair follicle stem cells significantly slows the hair growth cycle in adult mice but does not impact the maintenance of HFSC populations.

research Co-Loading of Finasteride and Baicalin in Phospholipid Vesicles Tailored for the Treatment of Hair Disorders

13 citations , January 2020 in “Nanoscale”

Finasteride and baicalin in phospholipid vesicles effectively promote hair growth and increase follicle count.

Protective Effects of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Dexamethasone-Induced Apoptotic Cell Death in Hair Follicles

research Protective Effects of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Dexamethasone-Induced Apoptotic Cell Death in Hair Follicles

12 citations , December 2019 in “International Journal of Molecular Medicine”

This study found that human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) significantly prevented hair loss induced by dexamethasone in a mouse model and enhanced cell proliferation in human hair follicle cells, suggesting a protective effect against stress-related hair loss.

The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression

research The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression

9 citations , November 2019 in “Scientific reports”

This study isolated a bioactive peptide from Trapa japonica fruit and found that it may protect human dermal papilla cells from DHT-induced stress, suggesting potential for biomedical applications.

research Hair Growth Promoting Effect of Houttuynia Cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells

16 citations , October 2019 in “Biological & Pharmaceutical Bulletin”

This study suggests that Houttuynia cordata extract may promote hair growth by stimulating dermal papilla cell proliferation and extending the anagen phase through enhanced energy metabolism and gene expression changes.

research BMP2-Mediated PTEN Enhancement Promotes Differentiation of Hair Follicle Stem Cells by Inducing Autophagy

24 citations , September 2019 in “Experimental cell research”

This study found that BMP2 increased PTEN expression and induced autophagy, promoting hair follicle stem cell differentiation in both in vitro models and a mouse wound model.

research Minoxidil And Its Use In Hair Disorders: A Review

117 citations , August 2019 in “Drug Design Development and Therapy”

This review article provides an updated overview of the pharmacology, mechanism of action, clinical efficacy, and adverse events associated with topical minoxidil, a widely used treatment for androgenetic alopecia and other hair loss conditions, while noting that its exact mechanism is still not fully understood.

research Hydroxytyrosol Prevents Dermal Papilla Cells Inflammation Under Oxidative Stress by Inducing Autophagy

13 citations , July 2019 in “Journal of Biochemical and Molecular Toxicology”

In this study on rat dermal papilla cells, hydroxytyrosol, an antioxidant found in olive oil, was reported to protect against oxidative stress, reduce inflammation, and enhance hair growth factors, suggesting its potential to prevent hair loss.

Integrative Analysis of Rare Copy Number Variants and Gene Expression Data in Alopecia Areata Implicates an Etiological Role for Autophagy

research Integrative Analysis of Rare Copy Number Variants and Gene Expression Data in Alopecia Areata Implicates an Etiological Role for Autophagy

20 citations , June 2019 in “Experimental Dermatology”

This study identified 14 genes affected by copy number variants that may contribute to alopecia areata, including four genes notably involved in autophagy and chromatin remodeling.

research Stimulation of Hair Growth by Small Molecules That Activate Autophagy

88 citations , June 2019 in “Cell reports”

This study found that activating autophagy with specific small molecules and drugs can stimulate hair growth by initiating the anagen phase in dormant hair follicles, suggesting a potential treatment for hair loss.

research Sexual Dysfunction in Men Taking Systemic Dermatologic Medication: A Systematic Review

11 citations , March 2019 in “Journal of The American Academy of Dermatology”

This review identifies evidence of sexual adverse effects, particularly linked to finasteride, in men using systemic dermatologic medications but reports no new clinical findings.

research Establishment and Characterization of a Radiation-Induced Dermatitis Rat Model

16 citations , February 2019 in “Journal of Cellular and Molecular Medicine”

This study established a rat model of radiation-induced dermatitis using 90 Gy irradiation, which may aid in exploring new treatments and understanding the pathology, particularly highlighting autophagy regulation as a potential therapeutic target.

research A Novel and Safe Small Molecule Enhances Hair Follicle Regeneration by Facilitating Metabolic Reprogramming

19 citations , December 2018 in “Experimental and Molecular Medicine”

This study reports that the novel small molecule IM176OUT05, by modifying stem cell metabolism, promoted hair regrowth and increased hair follicle numbers in mice.

Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation

research Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation

18 citations , October 2018 in “Nutrients”

This study found that Annurca apple polyphenolic extracts reprogram hair follicle metabolism in mice, enhancing mitochondrial activity and keratin production while inhibiting some metabolic pathways.

research Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter on Human Dermal Fibroblasts

68 citations , September 2018 in “International Journal of Molecular Sciences”

In this study, researchers found that exposure to PM10 significantly increased inflammation and impaired collagen synthesis in human dermal fibroblasts, suggesting PM10 contributes to skin aging through these mechanisms.

research Reversing Wrinkled Skin and Hair Loss in Mice by Restoring Mitochondrial Function

74 citations , June 2018 in “Cell death and disease”

In this study, researchers found that depleting mtDNA in mice caused skin wrinkles and hair loss but restoring mitochondrial function reversed these effects, highlighting mtDNA's significant role in skin and hair health.

research Serenoa Repens Extracts Promote Hair Regeneration and Repair of Hair Loss in Mouse Models by Activating TGF-β and Mitochondrial Signaling Pathway

24 citations , June 2018 in “PubMed”

This study found that liposterolic extracts of Serenoa repens enhanced hair regeneration and repair in DHT-induced hair loss mouse models, suggesting potential effects comparable to finasteride.

research Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases

80 citations , April 2018 in “Trends in Molecular Medicine”

This review discusses the roles of interferon-γ and PPAR-γ-mediated signalling in scarring alopecia, suggesting these pathways as potential therapeutic targets, but it reports no new empirical results.

research Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture

42 citations , March 2018 in “PLOS Biology”

This study found that autophagy plays a novel role in human hair growth, with altered autophagic flux during hair development phases influencing hair follicle behavior in a preclinical model.

research Hair Loss: Common Causes and Treatment

35 citations , September 2017 in “PubMed”

This article reviews different types of alopecia, their diagnosis, and treatment options available in a family physician's practice, but it reports no new research findings.

research Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation

202 citations , August 2017 in “Nature cell biology”

This study found that glycolytic metabolism and lactate production are crucial for hair follicle stem cell activation, and manipulating these processes can stimulate the hair cycle.

research Compartmentation of Mitochondrial and Oxidative Metabolism in Growing Hair Follicles: A Ring of Fire

40 citations , March 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study visualized mitochondrial metabolism in cultured bovine hair follicles and plucked human hairs, finding that ROS and mitochondrial polarization correlate in specific hair follicle regions, particularly near keratin deposition sites.

Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions

research Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions

56 citations , March 2015 in “Journal of Investigative Dermatology”

Healthy mitochondria in skin cells are essential for proper hair growth and skin cell interaction in mice.

research Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

93 citations , February 2015 in “Journal of Investigative Dermatology”

This study suggests that oxidative stress may contribute to androgenetic alopecia by inducing premature senescence and secretion of hair growth inhibitors in dermal papilla cells from balding scalp.

research Telogen Effluvium: A Review

70 citations , January 2015 in “Journal of Clinical and Diagnostic Research”

This review discusses the various triggers and diagnostic challenges in determining the cause of telogen effluvium-related hair loss, without providing new clinical results.

research A Review of Adipocyte Lineage Cells and Dermal Papilla Cells in Hair Follicle Regeneration

35 citations , January 2014 in “Journal of Tissue Engineering”

This review discusses recent advances in the role of dermal papilla cells and adipocyte lineage cells in hair regeneration, but it reports no new clinical results.

research Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

277 citations , February 2013 in “Science Signaling”

This study found that mitochondrial reactive oxygen species are crucial for normal epidermal differentiation and hair follicle growth, as demonstrated by impaired development in mice lacking these signals due to a keratinocyte-specific TFAM deficiency.

research Effects of Glucocorticoid on Human Dermal Papilla Cells In Vitro

27 citations , December 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that dexamethasone treatment reduced cell viability and growth factor expression in human dermal papilla cells, suggesting it inhibits hair growth.

research British Association of Dermatologists’ Guidelines for the Management of Alopecia Areata 2012

218 citations , April 2012 in “British Journal of Dermatology”

This updated guideline from the British Association of Dermatologists discusses current recommendations for managing alopecia areata but reports no new clinical research findings.

research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

717 citations , June 2010 in “Nature”

This study identified key genetic regions associated with alopecia areata, highlighting both acquired and innate immune involvement, with a novel link to the upregulation of ULBP ligands in autoimmune disease.

research Scratching the Surface of Skin Development

788 citations , February 2007 in “Nature”

This review explores how adult skin epithelia preserve stem cell populations for hair follicle regeneration and wound healing, but reports no new experimental results.

research Hair Growth Inhibition by Psychoemotional Stress: A Mouse Model for Neural Mechanisms in Hair Growth Control

127 citations , December 2005 in “Experimental Dermatology”

This study provides evidence that psychoemotional stress inhibits hair growth in mice by affecting the brain-hair follicle axis, with specific neuropeptides and treatments modulating this effect.

research Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss

116 citations , September 2001 in “Journal of The American Academy of Dermatology”

This study suggests that miniaturization in pattern hair loss may occur abruptly and can be reversed with treatment, as supported by histologic evidence in finasteride-responsive patients.

research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.

research A Murine Model for Inducing and Manipulating Hair Follicle Regression: Effects of Dexamethasone and Cyclosporin A

124 citations , August 1994 in “Journal of Investigative Dermatology”

This study found that applying dexamethasone to mice induced catagen-like follicle changes significantly earlier and more consistently than a vehicle, such changes being useful for studying hair follicle regression.