Autophagy Dysfunction: The Kernel of Hair Loss?

    Xu Jin, Xiuzu Song
    Studysummary In this study, researchers reviewed the roles of autophagy and mitophagy in hair follicle cycles, exploring their potential links to hair loss and investigating how manipulating these pathways might offer new therapeutic strategies.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on dovepress.com →
    Discuss this study in the Community →

    Research cited in this study 82

    1. Bioinspired Engineering of ADSC Nanovesicles in Thermosensitive Hydrogel to Enhance Autophagy of Dermal Papilla Cells for Androgenetic Alopecia Treatment Bioactive Materials · 2024
    2. Autophagy Induces Hair Follicle Stem Cell Activation and Hair Follicle Regeneration by Regulating Glycolysis 2024
    3. Activating Autophagy Promotes Skin Regeneration Induced by Mechanical Stretch During Tissue Expansion Burns and trauma · 2024
    4. Real-World Treatment Patterns Among Patients With Alopecia Areata in the USA: A Retrospective Claims Analysis Acta dermato-venereologica · 2023
    5. Autophagy Critically Controls Skin Inflammation and Apoptosis-Induced Stem Cell Activation Autophagy · 2023
    6. Therapeutic Effects of Topical Cetirizine in the Treatment of Female Pattern Hair Loss: A Randomized Controlled Noninferiority Trial Expert Review of Clinical Pharmacology · 2023
    7. Autophagy Controls the Protein Composition of Hair Shafts ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    8. Overview of the Circadian Clock in the Hair Follicle Cycle Biomolecules · 2023
    9. Oxidative Stress and Alopecia Areata Frontiers in medicine · 2023
    10. Novel Recombinant R-Spondin1 Promotes Hair Regeneration by Targeting the Wnt/β-Catenin Signaling Pathway Acta Biochimica et Biophysica Sinica · 2023
    11. The Crosstalk Between PTEN-Induced Kinase 1-Mediated Mitophagy and the Inflammasome in the Pathogenesis of Alopecia Areata Experimental Dermatology · 2023
    12. Male Pattern Hair Loss: Can Developmental Origins Explain the Pattern? Experimental Dermatology · 2023
    13. Androgenetic Alopecia: Therapy Update Drugs · 2023
    14. Novel Potential Therapeutic Targets of Alopecia Areata Frontiers in Immunology · 2023
    15. Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway International Journal of Molecular Sciences · 2023
    16. Trends in Prevalence and Incidence of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Among Adults and Children in a US Employer-Sponsored Insured Population JAMA Dermatology · 2023
    17. Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production International journal of molecular sciences · 2023
    18. Induction of Autophagy Improves Skin and Hair Conditions in Dogs with Underlying Diseases Frontiers in veterinary science · 2023
    19. Hair Follicles as a Critical Model for Monitoring the Circadian Clock International Journal of Molecular Sciences · 2023
    20. Alopecia Areata: A Review of the Role of Oxidative Stress, Possible Biomarkers, and Potential Novel Therapeutic Approaches Antioxidants · 2023
    21. Red Organic Light-Emitting Diodes Based Photobiomodulation Therapy Enabling Prominent Hair Growth Nano Research · 2023
    22. The AR/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia International Journal of Biological Sciences · 2023
    23. Limonin, a Component of Immature Citrus Fruits, Activates Anagen Signaling in Dermal Papilla Cells Nutrients · 2022
    24. Ginsenoside Re Prevents 3-Methyladenine-Induced Catagen Phase Acceleration by Regulating Wnt/Beta-Catenin Signaling in Human Dermal Papilla Cells Journal of Ginseng Research/Journal of ginseng research · 2022
    25. An Integrative Analysis of the LncRNA-MiRNA-mRNA Competitive Endogenous RNA Network Reveals Potential Mechanisms in the Murine Hair Follicle Cycle Frontiers in Genetics · 2022
    26. Autophagy: Guardian of Skin Barrier Biomedicines · 2022
    27. Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State Developmental cell · 2022
    28. 3D Spheroid Human Dermal Papilla Cell as an Effective Model for the Screening of Hair Growth Promoting Compounds: Examples of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid (TCQA) Cells · 2022
    29. Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging Frontiers in Cell and Developmental Biology · 2022
    30. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    31. 5-Bromo-3,4-Dihydroxybenzaldehyde Promotes Hair Growth Through Activation of Wnt/β-Catenin and Autophagy Pathways and Inhibition of TGF-β Pathways in Dermal Papilla Cells Molecules · 2022
    32. Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts Journal of Biomedical Science · 2022
    33. The Associated Burden of Mental Health Conditions in Alopecia Areata: A Population-Based Study in UK Primary Care British Journal of Dermatology · 2022
    34. Observations Suggesting a Contribution of Altered Dermal Papilla Mitochondrial Function to Androgenetic Alopecia Experimental Dermatology · 2022
    35. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    36. Understanding Causes of Hair Loss in Women Dermatologic Clinics · 2021
    37. Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss Journal of Medicinal Chemistry · 2021
    38. Myristoleic Acid Promotes Anagen Signaling by Autophagy Through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells Biomolecules & therapeutics · 2021
    39. Alopecia in Harlequin Mutant Mice Is Associated with Reduced AIF Protein Levels and Expression of Retroviral Elements Mammalian genome · 2020
    40. Common Causes of Hair Loss: Clinical Manifestations, Trichoscopy, and Therapy Journal of the European Academy of Dermatology and Venereology · 2020
    41. Impairment of Autophagy May Be Associated with Follicular Miniaturization in Androgenetic Alopecia by Inducing Premature Catagen Journal of Dermatology · 2020
    42. Novel Complex of Cosmetic Ingredients with Promising Action in Preventing Hair Loss and Follicular Aging Through Mechanism Involving Enrichment of WNT/Signaling, Mitochondrial Activity, and Stem Cells Maintenance Journal of Cosmetic Dermatology · 2020
    43. The biology of human hair greying Biological reviews/Biological reviews of the Cambridge Philosophical Society · 2020
    44. Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway Molecules · 2020
    45. Comparison of Mitochondrial Transplantation Using a Stamp-Type Multineedle Injector and Platelet-Rich Plasma Therapy for Hair Aging in Naturally Aging Mice Biomedicine & Pharmacotherapy · 2020
    46. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    47. Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells BMC complementary medicine and therapies · 2020
    48. Deficiency of Crif1 in Hair Follicle Stem Cells Retards Hair Growth Cycle in Adult Mice PloS one · 2020
    49. Co-Loading of Finasteride and Baicalin in Phospholipid Vesicles Tailored for the Treatment of Hair Disorders Nanoscale · 2020
    50. Protective Effects of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Dexamethasone-Induced Apoptotic Cell Death in Hair Follicles International Journal of Molecular Medicine · 2019
    51. The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression Scientific reports · 2019
    52. Hair Growth Promoting Effect of Houttuynia Cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells Biological & Pharmaceutical Bulletin · 2019
    53. BMP2-Mediated PTEN Enhancement Promotes Differentiation of Hair Follicle Stem Cells by Inducing Autophagy Experimental cell research · 2019
    54. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    55. Hydroxytyrosol Prevents Dermal Papilla Cells Inflammation Under Oxidative Stress by Inducing Autophagy Journal of Biochemical and Molecular Toxicology · 2019
    56. Integrative Analysis of Rare Copy Number Variants and Gene Expression Data in Alopecia Areata Implicates an Etiological Role for Autophagy Experimental Dermatology · 2019
    57. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    58. Sexual Dysfunction in Men Taking Systemic Dermatologic Medication: A Systematic Review Journal of The American Academy of Dermatology · 2019
    59. Establishment and Characterization of a Radiation-Induced Dermatitis Rat Model Journal of Cellular and Molecular Medicine · 2019
    60. A Novel and Safe Small Molecule Enhances Hair Follicle Regeneration by Facilitating Metabolic Reprogramming Experimental and Molecular Medicine · 2018
    61. Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation Nutrients · 2018
    62. Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter on Human Dermal Fibroblasts International Journal of Molecular Sciences · 2018
    63. Reversing Wrinkled Skin and Hair Loss in Mice by Restoring Mitochondrial Function Cell death and disease · 2018
    64. Serenoa Repens Extracts Promote Hair Regeneration and Repair of Hair Loss in Mouse Models by Activating TGF-β and Mitochondrial Signaling Pathway PubMed · 2018
    65. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018
    66. Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture PLOS Biology · 2018
    67. Hair Loss: Common Causes and Treatment PubMed · 2017
    68. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    69. Compartmentation of Mitochondrial and Oxidative Metabolism in Growing Hair Follicles: A Ring of Fire ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2017
    70. Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions Journal of Investigative Dermatology · 2015
    71. Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015
    72. Telogen Effluvium: A Review Journal of Clinical and Diagnostic Research · 2015
    73. A Review of Adipocyte Lineage Cells and Dermal Papilla Cells in Hair Follicle Regeneration Journal of Tissue Engineering · 2014
    74. Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development Science Signaling · 2013
    75. Effects of Glucocorticoid on Human Dermal Papilla Cells In Vitro The Journal of Steroid Biochemistry and Molecular Biology · 2012
    76. British Association of Dermatologists’ Guidelines for the Management of Alopecia Areata 2012 British Journal of Dermatology · 2012
    77. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    78. Scratching the Surface of Skin Development Nature · 2007
    79. Hair Growth Inhibition by Psychoemotional Stress: A Mouse Model for Neural Mechanisms in Hair Growth Control Experimental Dermatology · 2005
    80. Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss Journal of The American Academy of Dermatology · 2001
    81. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    82. A Murine Model for Inducing and Manipulating Hair Follicle Regression: Effects of Dexamethasone and Cyclosporin A Journal of Investigative Dermatology · 1994