Autophagy Dysfunction: The Kernel of Hair Loss?

    May 2024 in “ Clinical Cosmetic and Investigational Dermatology ”
    Xu Jin, Xiuzu Song
    Image of study
    TLDR Manipulating cell cleanup processes could help treat hair loss.
    The paper "Autophagy Dysfunction: The Kernel of Hair Loss?" investigates the role of autophagy in hair loss conditions like androgenetic alopecia (AGA) and alopecia areata (AA). Autophagy, essential for cellular health, is particularly active during the anagen phase of the hair cycle and crucial for hair follicle stem cell activation. Dysfunction in autophagy can lead to premature hair cycle transitions and hair loss. The study highlights that targeting autophagy pathways could offer new therapeutic strategies for treating alopecia. Treatments like human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) and autophagy promoters like spermidine show potential in mitigating hair loss by enhancing autophagy. The review underscores the need for further research to fully understand the mechanisms and develop targeted treatments for hair loss.
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