Bioinspired engineering ADSC nanovesicles thermosensitive hydrogel enhance autophagy of dermal papilla cells for androgenetic alopecia treatment

    June 2024 in “Bioactive Materials
    Jiachao Xiong, Zhixiao Liu, Lingling Jia, Yulin Sun, Ran Guo, Tingting Xi, Zihan Li, Minjuan Wu, Hua Jiang, Yufei Li
    TLDR New treatment using engineered nanovesicles in hydrogel improves hair growth by repairing hair follicle cells in a mouse model of hair loss.
    The study presents a new method for treating androgenetic alopecia (AGA) using engineered adipose-derived stem cell nanovesicles (ADSC-NVs) to promote hair regeneration. The researchers found that dermal papilla cells (DPCs) in hair follicles of AGA patients are damaged by dihydrotestosterone (DHT) and inflammation, which prevents hair follicles from entering the growth phase. The study introduced engineered ADSC-NVs with overexpressed Junctional Adhesion Molecule A (JAM-A) into thermosensitive hydrogels for efficient delivery of high-yield restorative JAM-A proteins. This treatment led to significant activation of the autophagy and Wnt/β-catenin pathways in DPCs in response to both DHT and macrophage-induced damage, and significantly improved hair regeneration in mice with AGA. The study suggests that this approach holds significant potential for clinical application in treating AGA.
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