Mesenchymal Stem Cells With Modification of Junctional Adhesion Molecule A Induce Hair Formation

    February 2014 in “ Stem cells translational medicine ”
    Minjuan Wu, Xiaohong Guo, Ling Yang, Yue Wang, Ying Tang, Yue Yang, Houqi Liu
    Image of study
    TLDR Modified stem cells that overexpress a specific protein can improve hair growth and reduce hair abnormalities in mice.
    In the 2014 study, researchers investigated the role of Junctional Adhesion Molecule A (JAM-A) in hair follicle regeneration by using human mesenchymal stem cells (MSCs) that were genetically modified to either overexpress or knockdown JAM-A. These modified MSCs were injected into the skin of BALB/c nu/nu mice during the first telogen phase of hair follicles. The results showed that MSCs with JAM-A overexpression (JAM-Aov MSCs) were able to migrate into the hair follicle sheath and effectively remodel the hair follicle structure, leading to improved hair formation and a significant reduction in hair follicle abnormalities such as curvature and zigzag patterns by 80% (p < .05). This was in contrast to the group with JAM-A knockdown (JAM-Akd MSCs) and the negative control group, which did not show these improvements. The study concluded that JAM-Aov MSCs can enhance hair formation in nude mice through the remodeling of hair follicle structures.
    Discuss this study in the Community →

    Research cited in this study

    10 / 10 results

    Related Community Posts Join

    6 / 92 results

      community Female AGA - Low Cortisol/Low DHEA

      in Female  7 upvotes 2 years ago
      Female (37) experiencing hair loss for 5 years, tried max dose of spiro and oral + topical minox without success. Discovered low cortisol and low DHEA levels, seeking functional medicine practitioner for help.

      community PP405 bandwagon, time to resume the hype train.

      in Treatment  166 upvotes 2 weeks ago
      PP405 shows promise in hair regrowth, potentially outperforming existing treatments like finasteride and minoxidil, with significant results in just four weeks. The treatment is still in early stages, with further trials needed to determine its long-term effectiveness and optimal dosage.

      community 5 years on finasteride only: age 21 to 26.

      in Progress Pictures  769 upvotes 2 months ago
      A user shared their five-year experience with finasteride for hair loss, noting positive results and no side effects. The discussion included debates on potential side effects like erectile dysfunction and the treatment's effectiveness.

      community Sharing what worked for me (PCOS related hair loss)

      in Female  35 upvotes 1 year ago
      A user with PCOS experienced hair loss and found success using a triple dose of O.N.E Omega by Pure Encapsulations after discovering low Omega fatty acids. Biotin provided minimal improvement, but the Omega supplement significantly restored hair.

      community DUT mesotherapy in Canada, any good references ?

      in Treatment  9 upvotes 2 years ago
      The conversation is about finding reputable clinics in Canada or near the US border that offer DUT mesotherapy for hair loss. The user is seeking recommendations and cost information for these treatments.

    Similar Research

    5 / 1000+ results