Mesenchymal Stem Cells With Modification of Junctional Adhesion Molecule A Induce Hair Formation

    February 2014 in “ Stem cells translational medicine ”
    Minjuan Wu, Xiaohong Guo, Ling Yang, Yue Wang, Ying Tang, Yue Yang, Houqi Liu
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    TLDR Modified stem cells that overexpress a specific protein can improve hair growth and reduce hair abnormalities in mice.
    In the 2014 study, researchers investigated the role of Junctional Adhesion Molecule A (JAM-A) in hair follicle regeneration by using human mesenchymal stem cells (MSCs) that were genetically modified to either overexpress or knockdown JAM-A. These modified MSCs were injected into the skin of BALB/c nu/nu mice during the first telogen phase of hair follicles. The results showed that MSCs with JAM-A overexpression (JAM-Aov MSCs) were able to migrate into the hair follicle sheath and effectively remodel the hair follicle structure, leading to improved hair formation and a significant reduction in hair follicle abnormalities such as curvature and zigzag patterns by 80% (p < .05). This was in contrast to the group with JAM-A knockdown (JAM-Akd MSCs) and the negative control group, which did not show these improvements. The study concluded that JAM-Aov MSCs can enhance hair formation in nude mice through the remodeling of hair follicle structures.
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