Mesenchymal Stem Cells With Modification of Junctional Adhesion Molecule A Induce Hair Formation

February 2014 in “ Stem cells translational medicine ”

Minjuan Wu, Xiaohong Guo, Ling Yang, Yue Wang, Ying Tang, Yue Yang, Houqi Liu

Junctional Adhesion Molecule A JAM-A mesenchymal stem cells MSCs hair follicle regeneration telogen phase hair follicle sheath hair follicle structure hair formation hair follicle abnormalities stem cells hair growth hair structure

TLDR Modified stem cells that overexpress a specific protein can improve hair growth and reduce hair abnormalities in mice.

In the 2014 study, researchers investigated the role of Junctional Adhesion Molecule A (JAM-A) in hair follicle regeneration by using human mesenchymal stem cells (MSCs) that were genetically modified to either overexpress or knockdown JAM-A. These modified MSCs were injected into the skin of BALB/c nu/nu mice during the first telogen phase of hair follicles. The results showed that MSCs with JAM-A overexpression (JAM-Aov MSCs) were able to migrate into the hair follicle sheath and effectively remodel the hair follicle structure, leading to improved hair formation and a significant reduction in hair follicle abnormalities such as curvature and zigzag patterns by 80% (p < .05). This was in contrast to the group with JAM-A knockdown (JAM-Akd MSCs) and the negative control group, which did not show these improvements. The study concluded that JAM-Aov MSCs can enhance hair formation in nude mice through the remodeling of hair follicle structures.

View this study on europepmc.org →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration

research Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration

78 citations, October 2012 in “Biomaterials”

Larger spheroids improve hair growth, but size doesn't guarantee thicker hair.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations, April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations, February 2009 in “Nature Reviews Molecular Cell Biology”

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

research Molecular Principles of Hair Follicle Induction and Morphogenesis

479 citations, January 2005 in “BioEssays”

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

research FOXN1 Is Critical for Onycholemmal Terminal Differentiation in Nude (Foxn1nu) Mice

58 citations, November 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

The Foxn1 gene is essential for normal nail and hair development.

Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

research Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

57 citations, June 2003 in “American Journal of Physiology-cell Physiology”

Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.

research Vitamin D3 Analogs Stimulate Hair Growth in Nude Mice

40 citations, October 2002 in “Endocrinology”

Vitamin D3 analogs can promote hair growth in mice genetically prone to hair loss.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations, January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

research The Biology of Hair Follicles

1113 citations, August 1999 in “The New England Journal of Medicine”

Hair follicle biology advancements may lead to better hair growth disorder treatments.

Ectopic Expression of the Nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

research Ectopic Expression of the Nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

69 citations, August 1999 in “Developmental biology”

The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.

Similar Research

5 / 1000+ results

research JAM-A Facilitates Hair Follicle Regeneration in Alopecia Areata Through Functioning as CeRNA to Protect VCAN Expression in Dermal Papilla Cells

August 2022 in “Precision Clinical Medicine”

JAM-A helps hair regrowth in alopecia areata by protecting VCAN in skin cells.

research Toll-Like Receptor 4 (TLR4): New Insights into Immunity and Aging

15 citations, November 2023 in “Immunity & ageing”

TLR4 is important in aging-related diseases and could be a new treatment target.

research The Dynamics of the Skin’s Immune System

306 citations, April 2019 in “International Journal of Molecular Sciences”

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

research Autophagy Dysfunction: The Kernel of Hair Loss?

May 2024 in “Clinical Cosmetic and Investigational Dermatology”

Manipulating cell cleanup processes could help treat hair loss.

research Wound Healing: A Cellular Perspective

1160 citations, November 2018 in “Physiological Reviews”

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.