Toll-Like Receptor 4 (TLR4): New Insights into Immunity and Aging
November 2023
in “
Immunity & ageing
”
TLDR TLR4 is important in aging-related diseases and could be a new treatment target.
The document "Toll-like receptor 4 (TLR4): new insight immune and aging" explores TLR4's role in immune responses and its connection to aging-related diseases. TLR4 activation leads to chronic inflammation, or "inflammaging," contributing to conditions like Alzheimer's, cancer, osteoarthritis, and sepsis. The review suggests that modulating TLR4 signaling could be a therapeutic strategy to mitigate these diseases. TLR4's involvement in neuroinflammation, cardiac disease, diabetes, and other conditions highlights its potential as a target for treating age-related disorders. Understanding TLR4's mechanisms offers new avenues for managing age-related inflammation and improving health outcomes.
