TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling

September 2023 in “ eLife ”

Luyang Xiong, Irina Zhevlakova, Xiaoxia Z. West, Detao Gao, Rakhilya Murtazina, Anthony Horak, J. Mark Brown, Iuliia Molokotina, Eugene A. Podrez, Tatiana V. Byzova

TLR2 hair follicle cycle hair follicle regeneration BMP signaling HFSCs CEP innate immunity hair regeneration hair follicle homeostasis hair growth hair loss treatments

TLDR TLR2 is important for hair growth and can be targeted to treat hair loss.

Our study reveals that TLR2 plays a crucial role in maintaining hair follicle homeostasis and regeneration by regulating HFSCs through BMP signaling. TLR2 expression is cycle-dependent and essential for HFSC activation. Aging and obesity reduce TLR2 and its ligand CEP, impairing hair regeneration. Administering CEP can stimulate hair growth via TLR2, highlighting a new link between innate immunity and hair follicle health, offering potential new treatments for hair loss.

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Research cited in this study

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