TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling

    September 2023 in “ eLife ”
    Luyang Xiong, Irina Zhevlakova, Xiaoxia Z. West … Tatiana V. Byzova
    Studysummary This study found that TLR2 expression in hair follicle stem cells is crucial for hair follicle maintenance and regeneration, with TLR2-dependent activation potentially offering new therapeutic approaches for hair loss prevention through mechanisms involving immune pathways and CEP administration.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 20

    1. TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling eLife · 2023
    2. Timely Wound Healing Is Dependent on Endothelial but Not on Hair Follicle Stem Cell Toll-Like Receptor 2 Signaling Journal of Investigative Dermatology · 2022
    3. Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence Nature · 2021
    4. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    5. Immune Modulation of Hair Follicle Regeneration npj Regenerative Medicine · 2020
    6. Injury Modifies the Fate of Hair Follicle Dermal Stem Cell Progeny in a Hair Cycle-Dependent Manner Experimental dermatology · 2019
    7. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    8. Role of Arachidonic Acid in Promoting Hair Growth Annals of dermatology/Annals of Dermatology · 2016
    9. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    10. Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations Cell · 2015
    11. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    12. Androgenetic Alopecia, Metabolic Syndrome, and Insulin Resistance: Is There Any Association? A Case-Control Study Indian Dermatology Online Journal · 2014
    13. Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation Proceedings of the National Academy of Sciences · 2013
    14. Age-Associated Inflammation Inhibits Epidermal Stem Cell Function Genes & development · 2012
    15. Inflammation in Androgenetic Alopecia and Hair Loss: Linking Neurosciences, Endocrinology, and Dermatology Hair transplant forum international · 2012
    16. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    17. Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells Science · 2011
    18. Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin The FASEB Journal · 2001
    19. Alopecia in Crash Dieters JAMA · 1976
    20. Alopecia in Crash Dieters PubMed · 1976

    Related research 6

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. Dermal Papilla-Derived Wnt Ligands Are Required for Adult Hair Follicle Growth Journal of Investigative Dermatology · 2016
    3. Putting the Human Hair Follicle Cycle on the Map Journal of Investigative Dermatology · 2016
    4. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    5. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    6. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000