TLDR Stress hormone corticosterone blocks a growth factor to slow down hair stem cell activity and hair growth.
In a study from March 31, 2021, researchers found that the stress hormone corticosterone, which is the rodent equivalent of cortisol in humans, plays a significant role in regulating hair follicle stem cell (HFSC) activity and hair growth in mice. The absence of corticosterone led to an increase in HFSC regeneration cycles, while chronic stress and elevated corticosterone levels caused prolonged HFSC quiescence and an extended resting phase for hair follicles. The hormone achieves this by suppressing the expression of Gas6, a gene responsible for producing growth arrest specific 6, a factor that promotes HFSC activation. When Gas6 expression was restored, it counteracted the stress-induced inhibition of HFSC activation and hair growth. This study highlights corticosterone as a key systemic inhibitor of HFSC activity, affecting the hair follicle niche and suggesting that managing stress or manipulating Gas6 expression could potentially be targeted for hair growth therapies.
Cited in this study
9 / 9 results
77 citations
,
August 2020 in “Cell” Muscles and nerves that cause goosebumps also help control hair growth.
75 citations
,
October 2016 in “Genes & Development” Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.
75 citations
,
August 2014 in “Journal of Investigative Dermatology” Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.
499 citations
,
September 2011 in “Cell” Fat-related cells are important for initiating hair growth.
314 citations
,
April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.
127 citations
,
May 2008 in “Journal of Investigative Dermatology” Mice hair growth patterns get more complex with age and can change with events like pregnancy or injury.
417 citations
,
September 2005 in “PLoS biology” Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.
194 citations
,
March 2003 in “American Journal of Pathology” Stress stops hair growth in mice by causing early hair growth phase end and harmful inflammation through a specific nerve-related pathway.
16 citations
,
July 1992 in “The journal of experimental zoology/Journal of experimental zoology” Adrenal glands delay the start of winter fur growth in mink.