Hair Regeneration: Mechano-Activation and Related Therapeutic Approaches

September 2025 in “ PubMed ”

Sun‐Young Nam, Shubham Jain, Amal George Kurian, Ishik Jeong, Byung Cheol Park, Kiwon Ban, Jonathan C. Knowles, Hae‐Won Kim

mechanical stimulation hair follicle stem cells WNT pathway BMP pathway macrophage recruitment growth factor release HGF IGF-1 MSC transplantation MSC secretome therapy platelet-rich plasma chimeric follicle development dermal papilla mesenchymal cell interactions PRP mesenchymal stem cell hepatocyte growth factor insulin-like growth factor 1

TLDR Mechanical stimulation and new therapies show promise for hair regrowth.

This review highlights recent advances in hair regeneration, focusing on mechanical stimulation and complementary treatments. Mechanical stimulation, such as skin stretching, activates hair follicle stem cells through WNT and BMP pathways, involving macrophage recruitment and growth factor release like HGF and IGF-1. Emerging therapies, including MSC transplantation, MSC secretome therapy, and platelet-rich plasma treatments, show promise in overcoming conventional therapy limitations. The review also explores molecular mechanisms, external influences, and novel processes like chimeric follicle development, emphasizing the role of dermal papilla and mesenchymal cell interactions in hair regrowth. These insights are expected to guide future research and clinical applications.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 11 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 11 months ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community If we can clone a sheep why we can't cure baldness till now

in Research/Science 181 upvotes 2 weeks ago

Hair loss treatments like Minoxidil, finasteride, and stem cell therapies exist, but a complete cure is hindered by genetic complexity and market dynamics. Cloning hair follicles is considered a potential solution, but it's currently not feasible.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Solving Hair Loss with Research at MIT

in Research/Science 595 upvotes 11 months ago

Hair loss treatments like minoxidil, finasteride, TDM-105795, and PP405. MIT is hosting a hackathon to find innovative hair loss solutions.

community I am actually regrowing my hairline without minoxidil or finasteride (mechanical stimulation)

127 upvotes 7 years ago

Regrowing hairline without the use of Minoxidil or Finasteride, and instead using mechanical stimulation such as Derma Roller, Nizoral, Zinc Pyrithione, Scalp Massage, Scalp Exercise, Fish Oil and other topical solutions. It is cautioned that there are risks associated with not using medically-prescribed treatments, but it is suggested to consider mechanical stimulation in addition to those prescribed treatments.

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