Multi-Stage Transcriptome Analysis Revealed the Growth Mechanism of Feathers and Hair Follicles During Induction Molting by Fasting in the Late Stage of Egg Laying

October 2023 in “ Biology ”

Lujie Zhang, Chunxia Cai, Xinxin Liu, Xiaoran Zhang, Zhiyuan An, Enting Zhou, Jianzeng Li, Zhuanjian Li, Wenting Li, Guirong Sun, Guoxi Li, Xiangtao Kang, Ruili Han, Ruirui Jiang

hair follicles thyroid hormones triiodothyronine tetraiodothyronine calcium signaling thyroid hormone synthesis thyroid hormone signaling pathways T3 T4

TLDR Fasting in hens affects thyroid hormones, which regulate feather and hair growth.

This study investigates the molecular mechanisms behind feather and hair follicle growth during fasting-induced molting in late-stage egg-laying hens. By using hematoxylin-eosin staining, hormone assays, and RNA sequencing, the researchers identified key genes (DSP, CDH1, PKP1, PPCKB) and pathways involved in this process. Significant changes in thyroid hormones (triiodothyronine and tetraiodothyronine) and calcium content were observed during feather shedding and regrowth. The study highlights the role of thyroid hormone synthesis, calcium signaling, and thyroid hormone signaling pathways in regulating feather molting, providing valuable insights into the cyclical growth of hair follicles during induced molting.

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Multi-Stage Transcriptome Analysis Revealed the Growth Mechanism of Feathers and Hair Follicles During Induction Molting by Fasting in the Late Stage of Egg Laying

Research cited in this study

research Single-Cell Transcriptomics Defines Keratinocyte Differentiation in Avian Scutate Scales

research Molecular Signaling and Nutritional Regulation in the Context of Poultry Feather Growth and Regeneration

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