Multi-Stage Transcriptome Analysis Revealed the Growth Mechanism of Feathers and Hair Follicles During Induction Molting by Fasting in the Late Stage of Egg Laying
October 2023
in “
Biology
”
TLDR Fasting in hens affects thyroid hormones, which regulate feather and hair growth.
This study investigates the molecular mechanisms behind feather and hair follicle growth during fasting-induced molting in late-stage egg-laying hens. By using hematoxylin-eosin staining, hormone assays, and RNA sequencing, the researchers identified key genes (DSP, CDH1, PKP1, PPCKB) and pathways involved in this process. Significant changes in thyroid hormones (triiodothyronine and tetraiodothyronine) and calcium content were observed during feather shedding and regrowth. The study highlights the role of thyroid hormone synthesis, calcium signaling, and thyroid hormone signaling pathways in regulating feather molting, providing valuable insights into the cyclical growth of hair follicles during induced molting.
