An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities

December 2020 in “ Frontiers in Cell and Developmental Biology ”

Patrycja Daszczuk, Paula Mazurek, Tomasz D. Pieczonka, Alicja Olczak, Łukasz M. Boryń, Krzysztof Kobielak

hair follicle stem cells hfSCs BMP signaling pathway WNT signaling pathway dermal papilla DP hair cycle regeneration stemness quiescence activation phases niche signals hair stem cells bone morphogenetic protein wingless-related integration site hair growth cycle stem cell activity resting phase growth phase environmental signals

TLDR Gene network oscillations inside hair stem cells are key for hair growth regulation and could help treat hair loss.

The document from December 10, 2020, reviews the molecular mechanisms that regulate hair follicle stem cells (hfSCs), focusing on the intrinsic oscillation of gene networks that modulate the balance between quiescence and activation phases. It emphasizes the importance of the BMP and WNT signaling pathways in maintaining hfSC homeostasis and the role of external niche signals, such as those from the dermal papilla (DP), in influencing hfSC behavior. The study suggests that the intrinsic oscillation of gene networks within hfSCs, along with the surrounding niche components, is crucial for regulating hair cycle regeneration. This understanding could lead to advancements in regenerative medicine and therapies for hair loss conditions. The document also discusses the role of various markers and signaling pathways in hfSC stemness and activation, the interplay between different skin cell populations, and the potential for new therapeutic targets for hair-related conditions.

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