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GlossaryStemness

ability to self-renew and differentiate into specialized cells

Stemness refers to the unique properties that define a stem cell, including its ability to self-renew (make copies of itself) and differentiate (develop into different types of specialized cells). This concept is crucial in both developmental biology and regenerative medicine, as it underpins the potential of stem cells to repair or replace damaged tissues, including hair follicles in cases of alopecia.

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research The Senescence–Stemness Alliance: A Cancer-Hijacked Regeneration Principle

68 citations, September 2018 in “Trends in Cell Biology”

Cancer can hijack the body's cell repair system to promote tumor growth, and targeting this process may improve cancer treatments.

research Activation of TLR3 Enhances Stemness and Immunomodulatory Properties of Periodontal Ligament Stem Cells

3 citations, December 2016 in “Springer eBooks”

Activating TLR3 improves the healing and immune properties of periodontal ligament stem cells.

research Novel In Vitro Culture Condition Improves the Stemness of Human Dermal Stem/Progenitor Cells

18 citations, November 2013 in “Molecules and Cells”

New culture method keeps human skin stem cells more stem-like.

research Age-Dependent Loss of the Stemness and Antimicrobial Defense Function of Dermal Fibroblasts Is Mediated by TGFbeta

April 2018 in “Journal of Investigative Dermatology”

Aging reduces skin cell renewal and defense against germs due to TGFbeta, but blocking TGFbeta could help restore these functions.

research Keratin-6 Driven ODC Expression in Hair Follicle Keratinocytes Enhances Stemness and Tumorigenesis by Negatively Regulating Notch

8 citations, August 2014 in “Biochemical and Biophysical Research Communications”

ODC overexpression in hair cells increases tumor growth by reducing Notch signaling.

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community The Real Cause Of Androgenetic Alopecia

in Research/Science 676 upvotes 6 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.