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GlossaryStemness

ability to self-renew and differentiate into specialized cells

Stemness refers to the unique properties that define a stem cell, including its ability to self-renew (make copies of itself) and differentiate (develop into different types of specialized cells). This concept is crucial in both developmental biology and regenerative medicine, as it underpins the potential of stem cells to repair or replace damaged tissues, including hair follicles in cases of alopecia.

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research The Senescence–Stemness Alliance: A Cancer-Hijacked Regeneration Principle

68 citations , September 2018 in “Trends in Cell Biology”

Cancer can hijack the body's cell repair system to promote tumor growth, and targeting this process may improve cancer treatments.

research Two Opposing Faces of Retinoic Acid: Induction of Stemness or Differentiation Depending on Cell Type

41 citations , October 2019 in “Biomolecules”

Retinoic acid can either maintain stem cells or make them specialize, depending on the cell type.

research Multiomics Global Landscape of Stemness-Related Gene Clusters in Adipose-Derived Mesenchymal Stem Cells

13 citations , July 2020 in “Stem Cell Research & Therapy”

Young donor, early passage stem cells have the highest stemness.

research Activation of TLR3 Enhances Stemness and Immunomodulatory Properties of Periodontal Ligament Stem Cells

3 citations , December 2016 in “Springer eBooks”

Activating TLR3 improves the healing and immune properties of periodontal ligament stem cells.

research Comparative Analysis of Stemness Between Dermal Papilla Cells and Human Dermal Stem/Progenitor Cells

April 2025 in “Cellular and Molecular Biology”

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community The Real Cause Of Androgenetic Alopecia

in Research/Science 673 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.