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    Glossary Stemness

    ability to self-renew and differentiate into specialized cells

    Stemness refers to the unique properties that define a stem cell, including its ability to self-renew (make copies of itself) and differentiate (develop into different types of specialized cells). This concept is crucial in both developmental biology and regenerative medicine, as it underpins the potential of stem cells to repair or replace damaged tissues, including hair follicles in cases of alopecia.

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    Research 30 of 803

    1. Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer Nature Reviews Genetics · 2018 · 124 citations
    2. The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle Trends in Cell Biology · 2018 · 68 citations
    3. Two Opposing Faces of Retinoic Acid: Induction of Stemness or Induction of Differentiation Depending on Cell-Type Biomolecules · 2019 · 41 citations
    4. Multiomics global landscape of stemness-related gene clusters in adipose-derived mesenchymal stem cells Stem Cell Research & Therapy · 2020 · 13 citations
    5. Aged differentiated cells reverse into native stemness-like state by niche cytokines to sustain lifelong homeostasis and tissue repair Nature Communications · 2026
    6. Mesothelial Stem Cells and Stromal Vascular Fraction for Skin Rejuvenation Facial Plastic Surgery Clinics of North America · 2018 · 11 citations
    7. Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells International Journal of Molecular Sciences · 2013 · 83 citations
    8. LncRNA PlncRNA‑1 regulates proliferation and differentiation of hair follicle stem cells through TGF‑β1‑mediated Wnt/β‑catenin signal pathway Molecular Medicine Reports · 2017 · 25 citations
    9. Activation of TLR3 Enhance Stemness and Immunomodulatory Properties of Periodontal Ligament Stem Cells (PDLSCs) Springer eBooks · 2016 · 3 citations
    10. Comparative analysis of stemness between dermal papilla cells and human dermalstem/progenitor cells Cellular and Molecular Biology · 2025
    11. Effects of MRI on Stemness Properties of Wharton’s Jelly Derived Mesenchymal Stem Cells Research Square (Research Square) · 2021
    12. p63: a crucial player in epithelial stemness regulation Oncogene · 2023 · 54 citations
    13. Novel in vitro culture condition improves the stemness of human dermal stem/progenitor cells Molecules and Cells · 2013 · 18 citations
    14. Dauricine attenuates Oct4/sonic hedgehog co‐activated stemness and induces reactive oxygen species‐mediated mitochondrial apoptosis via AKT/β‐catenin signaling in human neuroblastoma and glioblastoma stem‐like cells Phytotherapy Research · 2023 · 5 citations
    15. 1325 Age-dependent loss of the stemness and antimicrobial defense function of dermal fibroblasts is mediated by TGFbeta Journal of Investigative Dermatology · 2018
    16. Biomimetic cell-adhesive ligand-functionalized peptide composite hydrogels maintain stemness of human amniotic mesenchymal stem cells Regenerative Biomaterials · 2021 · 14 citations
    17. Activation and regulation of the granulation tissue derived cells with stemness-related properties Stem Cell Research & Therapy · 2015 · 14 citations
    18. Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch Biochemical and Biophysical Research Communications · 2014 · 8 citations
    19. Understanding the molecular basis of mesenchymal stem cell stemness: implications for clinical applications Cell Death and Disease · 2025 · 1 citations
    20. Inhibition of the Hippo pathway by verteporfin reduces the proliferation and stemness of rat hair follicle neural crest stem cells under hypoxia FASEB BioAdvances · 2025
    21. Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles American Journal Of Pathology · 2006 · 344 citations
    22. Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation Stem Cell Research & Therapy · 2017 · 316 citations
    23. Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011 · 191 citations
    24. Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition Cell stem cell · 2016 · 174 citations
    25. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020 · 23 citations
    26. Ginsenoside Rg3 Up-regulates the Expression of Vascular Endothelial Growth Factor in Human Dermal Papilla Cells and Mouse Hair Follicles 2013 · 20 citations
    27. A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming Experimental and Molecular Medicine · 2018 · 19 citations
    28. Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632 Frontiers in cell and developmental biology · 2021 · 16 citations
    29. Enhanced viability and neural differential potential in poor post-thaw hADSCs by agarose multi-well dishes and spheroid culture Human Cell · 2015 · 15 citations
    30. Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β‐catenin signalling and promotes hair regrowth British Journal of Pharmacology · 2023 · 11 citations