Altered Skin Development and Impaired Proliferative and Inflammatory Responses in Transgenic Mice Overexpressing the Glucocorticoid Receptor

    July 2001 in “ The FASEB Journal ”
    Paloma Pérez, Angustias Page, Ana Bravo … José L. Jorcano
    Studysummary In this study, transgenic mice overexpressing the glucocorticoid receptor in certain epithelia showed skin development abnormalities resembling ectodermal dysplasia and exhibited reduced inflammatory responses.
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    Research cited in this study 2

    1. Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development PubMed · 1997
    2. Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure. The EMBO Journal · 1995

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