Dysregulated Behavior of Hair Follicle Stem Cells Triggers Alopecia and Provides Potential Therapeutic Targets

    May 2022 in “ Experimental Dermatology
    Yuanhong Liu, Shengbo Yang, Yilan Zeng, Ziting Tang, Xiule Zong, Xuemei Li, Caifeng Yang, Lulu Liu, Xiaoliang Tong, Linying Zhou, Dan Wang
    Image of study
    TLDR Misbehaving hair follicle stem cells can cause hair loss and offer new treatment options.
    The document discusses the role of hair follicle stem cell (HFSC) behavior in alopecia, a condition causing hair loss. Dysregulated HFSC behavior, influenced by factors such as HFSC metabolism, aging, and the microenvironment, can lead to hair growth disorders. Potential therapeutic targets include lactate generation, pyruvate entry into mitochondria, the transcription factor nuclear factor of activated T cell c1 (Nfatc1), and Breast cancer susceptibility gene 1 (BRCA1). The study also highlights the role of the extracellular matrix (ECM) and various cells and signals in the HFSC microenvironment in hair regeneration disorders. Manipulating these components could provide novel therapeutic strategies for hair loss. The study by Wen et al. demonstrated that human HFSCs cultured with the Rho-associated protein kinase (ROCK) inhibitor Y-27632 showed enhanced adhesion and proliferation, maintaining stemness and enhancing hair follicle regeneration. MicroRNAs, such as miR-22-5p and miR-214, were identified as potential therapeutic targets for hair loss. The review concluded that a better understanding of HFSC behavior could lead to the development of therapeutic strategies for alopecia.
    Discuss this study in the Community →

    Research cited in this study

    28 / 28 results

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  43 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  140 upvotes 9 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

    Related Research

    5 / 5 results