The Endocannabinoid System of the Skin: A Potential Approach for the Treatment of Skin Disorders

The document reviewed the role of the endocannabinoid system (ECS) in maintaining skin health and its involvement in various skin disorders such as atopic dermatitis, psoriasis, scleroderma, and skin cancer. It highlighted that dysregulation of the ECS is linked to these conditions and suggested that targeting the ECS could offer new treatment avenues. The review emphasized that phytocannabinoids and their analogues can modulate ECS through various receptors and channels, and that a multi-target approach might be more effective than traditional single-target drug discovery methods.