Cannabinoids and Their Receptors in Skin Diseases

    November 2023 in “ International journal of molecular sciences ”
    Eun Hee Yoo, Ji Hyun Lee
    TLDR Cannabinoids might help treat skin problems but more research is needed to be sure.
    The article "Cannabinoids and Their Receptors in Skin Diseases" examines the potential therapeutic benefits of cannabinoids like CBD and THC in treating skin conditions such as eczema, psoriasis, acne, pruritus, and skin cancer. Cannabinoids interact with CB1 and CB2 receptors to modulate inflammation, reduce cytokine production, and inhibit mast cell growth. Clinical trials have shown promising results, such as a 58.6% reduction in symptoms for 2,456 atopic dermatitis patients using PEA and significant improvements in psoriasis with 2.5% CBD ointment. Despite these positive findings, further research and large-scale clinical trials are needed to fully understand and optimize cannabinoid-based treatments for skin diseases.
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